Performance of renal Doppler to predict the occurrence of acute kidney injury in patients without acute kidney injury at admission.
Acute kidney injury
Doppler
Resistive index
Sensitivity
Specificity
Journal
Journal of critical care
ISSN: 1557-8615
Titre abrégé: J Crit Care
Pays: United States
ID NLM: 8610642
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
06
09
2021
revised:
13
12
2021
accepted:
31
12
2021
pubmed:
26
1
2022
medline:
4
5
2022
entrez:
25
1
2022
Statut:
ppublish
Résumé
This study aimed at evaluating the performance of Doppler-based resistive index (RI) and semi-quantitative evaluation of renal perfusion using color-Doppler (SQP) to predict de novo AKI in the subgroup of critically ill patients without AKI at admission. This study is an ancillary analysis of a prospective multicenter cohort study. Consecutive ICU patients requiring mechanical ventilation were included. Renal Doppler was performed at ICU admission. The diagnostic performance of RI and SQP to predict de novo AKI at day 3 was evaluated. Among the 371 patients of the prospective cohort, 118 without AKI at study inclusion were included. Thirty-four patients (29%) developed an AKI. Neither RI (0.64 UI [0.57-0.70] vs 0.67 [0.62-0.70] in no AKI and de novo AKI group respectively, p = 0.177) nor SQP (2 [2, 3] vs 2 [1-3] in no AKI and de novo AKI group respectively, p = 0.061) were associated with AKI occurrence. Overall performance in predicting de novo AKI was null to poor with area under ROC curve of respectively 0.60 (95% CI 0.49-0.65) and 0.58 (95% CI 0.47-0.60) for RI and SQP. Similar results were obtained after adjustment for confounders. These results confirm the poor performance of Doppler-based indices in predicting renal prognosis of ICU patients.
Identifiants
pubmed: 35074631
pii: S0883-9441(22)00001-6
doi: 10.1016/j.jcrc.2021.12.017
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT02355314']
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
153983Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest M.D. declare having received administrative support from his former institution (Saint-Etienne University Hospital) to conduct this study and having received research support from Astute Medical unrelated to the current study. Outside the scope of this study, MD declare having received grant from MSD, speaker fees from MSD, Astelas and Gilead-Kite and having attended an advisory board for Gilead-Kite. The other authors declare having no other conflict of interest related to this manuscript.