Female fertility and the zona pellucida.
cell biology
fertility
genetics
mutations
oogenesis
zona pellucida
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
25 01 2022
25 01 2022
Historique:
received:
06
12
2021
accepted:
07
01
2022
entrez:
25
1
2022
pubmed:
26
1
2022
medline:
5
3
2022
Statut:
epublish
Résumé
Fertility in female mammals, including mice and humans, is dependent on the presence of a zona pellucida (ZP) around growing oocytes and unfertilized eggs. A ZP is required to stabilize contacts between oocyte microvilli and follicle cell projections that traverse the ZP to form gap junctions that support the health of growing oocytes and developing follicles. In the absence of a ZP, due to inactivation or mutation of genes encoding ZP proteins, there is a loss of contacts between growing oocytes and neighboring follicle cells and a concomitant reduction in the production of ovulated eggs that results in female infertility.
Identifiants
pubmed: 35076396
doi: 10.7554/eLife.76106
pii: 76106
pmc: PMC8789258
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NICHD NIH HHS
ID : R01 HD035105
Pays : United States
Informations de copyright
© 2022, Wassarman and Litscher.
Déclaration de conflit d'intérêts
PW, EL No competing interests declared
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