Comparing qPCR and DNA methylation-based measurements of telomere length in a high-risk pediatric cohort.

Aged Aging / genetics Cohort Studies DNA Methylation Humans Male Reproducibility of Results Telomere / genetics
DNAmTL agreement pediatric qPCR telomere length

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
24 01 2022
Historique:
received: 18 10 2021
accepted: 17 01 2022
pubmed: 26 1 2022
medline: 14 4 2022
entrez: 25 1 2022
Statut: ppublish

Résumé

Various approaches exist to assess population differences in biological aging. Telomere length (TL) is one such measure, and is associated with disease, disability and early mortality. Yet, issues surrounding precision and reproducibility are a concern for TL measurement. An alternative method to estimate TL using DNA methylation (DNAmTL) was recently developed. Although DNAmTL has been characterized in adult and elderly cohorts, its utility in pediatric populations remains unknown. We examined the comparability of leukocyte TL measurements generated using qPCR (absolute TL; aTL) to those estimated using DNAmTL in a high-risk pediatric cohort (

Identifiants

DOI: 10.18632/aging.203849 PMID: 35077392 PMC: PMC8833135
pubmed: 35077392
pii: 203849
doi: 10.18632/aging.203849
pmc: PMC8833135
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

660-677

Subventions

Organisme : NICHD NIH HHS
ID : P50 HD089922
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG049676
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES030949
Pays : United States

Références

PLoS One. 2017 Sep 8;12(9):e0184098
pubmed: 28886139
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Nat Protoc. 2010 Sep;5(9):1596-607
pubmed: 21085125
Cancer Epidemiol Biomarkers Prev. 2013 Nov;22(11):2047-54
pubmed: 24019396
Nature. 1991 Apr 18;350(6319):569-73
pubmed: 1708110
Circ Cardiovasc Genet. 2015 Feb;8(1):82-90
pubmed: 25406241
Front Genet. 2021 Sep 17;12:728603
pubmed: 34603389
Dev Psychopathol. 2021 May;33(2):394-408
pubmed: 33955343
Mech Ageing Dev. 2008 Nov;129(11):638-41
pubmed: 18765247
Cells. 2018 Oct 24;7(11):
pubmed: 30352968
Psychoneuroendocrinology. 2020 Mar;113:104484
pubmed: 31918390
Neurosci Lett. 2003 Mar 13;339(1):62-6
pubmed: 12618301
J Pediatr. 2011 Feb;158(2):215-20
pubmed: 20855079
PLoS One. 2019 May 1;14(5):e0216118
pubmed: 31042766
Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4104-10
pubmed: 26150497
FASEB J. 2019 Dec;33(12):14248-14253
pubmed: 31652401
Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15122-15127
pubmed: 31285335
Int J Cancer. 2011 Aug 15;129(4):983-92
pubmed: 21351086
Lancet. 1986 Feb 8;1(8476):307-10
pubmed: 2868172
Aging Cell. 2013 Aug;12(4):615-21
pubmed: 23601089
BMC Bioinformatics. 2012 May 08;13:86
pubmed: 22568884
Exp Hematol. 2010 Oct;38(10):854-9
pubmed: 20600576
Mol Psychiatry. 2018 Apr;23(4):858-871
pubmed: 28322278
Ageing Res Rev. 2013 Mar;12(2):509-19
pubmed: 23333817
Sci Rep. 2017 Aug 21;7(1):8962
pubmed: 28827677
Mol Biol Rep. 2018 Aug;45(4):633-638
pubmed: 29623565
Arch Dis Child. 1969 Jun;44(235):291-303
pubmed: 5785179
Nucleic Acids Res. 2002 May 15;30(10):e47
pubmed: 12000852
Nucleic Acids Res. 2009 Feb;37(3):e21
pubmed: 19129229
Psychoneuroendocrinology. 2019 Aug;106:171-178
pubmed: 30999227
Psychoneuroendocrinology. 2013 Sep;38(9):1835-42
pubmed: 23639252
Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741):
pubmed: 29335378
Int J Mol Sci. 2020 Jan 17;21(2):
pubmed: 31963520
Eur J Hum Genet. 2013 Oct;21(10):1163-8
pubmed: 23321625
Biol Proced Online. 2011 Jan 31;13:3
pubmed: 21369534
Ageing Res Rev. 2018 Dec;48:11-20
pubmed: 30254001
Arch Dis Child. 1970 Feb;45(239):13-23
pubmed: 5440182
Dev Psychopathol. 2016 Nov;28(4pt2):1367-1383
pubmed: 27688015
Epidemiol Rev. 2013;35:112-31
pubmed: 23302541
Lancet. 2005 Aug 20-26;366(9486):662-4
pubmed: 16112303
Elife. 2020 May 05;9:
pubmed: 32367804
Diabetologia. 2016 Jun;59(6):1258-65
pubmed: 27020448
Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):e114-7
pubmed: 16627805
Proc Natl Acad Sci U S A. 1998 May 12;95(10):5607-10
pubmed: 9576930
Int J Epidemiol. 2015 Oct;44(5):1673-83
pubmed: 25239152
Hum Mol Genet. 2007 Dec 15;16(24):3097-102
pubmed: 17881651
Int J Epidemiol. 2016 Aug;45(4):1295-1298
pubmed: 27581804
J Youth Adolesc. 1988 Apr;17(2):117-33
pubmed: 24277579
Aging (Albany NY). 2019 Aug 18;11(16):5895-5923
pubmed: 31422385
J Gerontol A Biol Sci Med Sci. 2011 Mar;66(3):312-9
pubmed: 21310811
Front Genet. 2017 Nov 22;8:164
pubmed: 29213278
Biol Psychiatry. 2019 Feb 1;85(3):268-278
pubmed: 30391001
Aging Cell. 2005 Apr;4(2):97-101
pubmed: 15771613
Aging (Albany NY). 2017 Apr;9(4):1130-1142
pubmed: 28394764
Exp Results. 2020;1:
pubmed: 33718773
Mol Psychiatry. 2013 May;18(5):576-81
pubmed: 22525489
Nucleic Acids Res. 2013 Jul;41(13):e131
pubmed: 23671336
Mutat Res. 2012 Feb 1;730(1-2):59-67
pubmed: 21663926
Aging (Albany NY). 2021 Jun 3;13(11):14675-14686
pubmed: 34083495
Sci Rep. 2019 Jul 17;9(1):10359
pubmed: 31316106

Auteurs

Waylon J Hastings (WJ)

Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA.

Laura Etzel (L)

Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA.

Christine M Heim (CM)

Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA.
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Institute of Medical Psychology, Berlin, Germany.

Jennie G Noll (JG)

Department of Human Development and Family Studies, The Pennsylvania State University, University Park, PA 16802, USA.

Emma J Rose (EJ)

Department of Human Development and Family Studies, The Pennsylvania State University, University Park, PA 16802, USA.
The Edna Bennett Pierce Prevention Research Center, The Pennsylvania State University, University Park, PA 16802, USA.

Hannah M C Schreier (HMC)

Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA.

Chad E Shenk (CE)

Department of Human Development and Family Studies, The Pennsylvania State University, University Park, PA 16802, USA.
Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Xin Tang (X)

Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA.

Idan Shalev (I)

Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Comparing qPCR and DNA methylation-based...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Comparing qPCR and DNA methylation-based...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Comparing qPCR and DNA methylation-based...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Comparing qPCR and DNA methylation-based...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Comparing qPCR and DNA methylation-based...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Comparing qPCR and DNA methylation-based...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Télomère › Comparing qPCR and DNA methylation-based...