Hybrid Compounds Containing Carvacrol Scaffold:

Anti-Bacterial Agents / pharmacology Anti-Infective Agents / chemistry Antifungal Agents / chemistry Antineoplastic Agents / pharmacology Antioxidants / chemistry Cymenes Microbial Sensitivity Tests Oils, Volatile / chemistry
Gram-negative bacteria Gram-positive bacteria antibacterial anticancer carvacrol hybrid compounds

Journal

Recent advances in anti-infective drug discovery
ISSN: 2772-4352
Titre abrégé: Recent Adv Antiinfect Drug Discov
Pays: United Arab Emirates
ID NLM: 9918266300206676

Informations de publication

Date de publication:
2022
Historique:
received: 29 08 2021
revised: 10 11 2021
accepted: 03 12 2021
pubmed: 27 1 2022
medline: 12 10 2022
entrez: 26 1 2022
Statut: ppublish

Résumé

The design of hybrid compounds is a distinct approach for developing potent bioactive agents. Carvacrol, an essential oil, exhibits antimicrobial, antifungal, antioxidant, and anticancer activity, making it a good precursor for the development of compounds with potent biological activities. Some patents have reported carvacrol derivatives with promising biological activities. This study aimed to prepare hybrid compounds containing a carvacrol scaffold with significant antibacterial and anticancer activity. Esterification reactions between carvacrol and known pharmacophores were performed at room temperature and characterized using The FTIR spectra of the carvacrol hybrids revealed prominent bands in the range of 1612-1764 cm The modification of carvacrol through hybridization is a promising approach to develop compounds with significant antibacterial and anticancer activity.

Sections du résumé

BACKGROUND BACKGROUND
The design of hybrid compounds is a distinct approach for developing potent bioactive agents. Carvacrol, an essential oil, exhibits antimicrobial, antifungal, antioxidant, and anticancer activity, making it a good precursor for the development of compounds with potent biological activities. Some patents have reported carvacrol derivatives with promising biological activities.
OBJECTIVE OBJECTIVE
This study aimed to prepare hybrid compounds containing a carvacrol scaffold with significant antibacterial and anticancer activity.
METHODS METHODS
Esterification reactions between carvacrol and known pharmacophores were performed at room temperature and characterized using
RESULTS RESULTS
The FTIR spectra of the carvacrol hybrids revealed prominent bands in the range of 1612-1764 cm
CONCLUSION CONCLUSIONS
The modification of carvacrol through hybridization is a promising approach to develop compounds with significant antibacterial and anticancer activity.

Identifiants

DOI: 10.2174/1574891X16666220124122445 PMID: 35078393
pubmed: 35078393
pii: RAAIDD-EPUB-120362
doi: 10.2174/1574891X16666220124122445
doi:

Substances chimiques

Anti-Bacterial Agents 0
Anti-Infective Agents 0
Antifungal Agents 0
Antineoplastic Agents 0
Antioxidants 0
Cymenes 0
Oils, Volatile 0
carvacrol 9B1J4V995Q

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

54-68

Informations de copyright

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Auteurs

Zintle Mbese (Z)

Department of Chemistry, Faculty of Science and Agriculture, University of Fort Hare, Alice, South Africa.

Margo Nell (M)

Department of Pharmacology, Faculty of Health Sciences, University of Pretoria, South Africa.

Youmbi T Fonkui (YT)

Department of Biotechnology and Food Technology, University of Johannesburg, Doornfontein Campus, Johannesburg, South Africa.

Derek T Ndinteh (DT)

Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus, Johannesburg, South Africa.

Vanessa Steenkamp (V)

Department of Pharmacology, Faculty of Health Sciences, University of Pretoria, South Africa.

Blessing A Aderibigbe (BA)

Department of Chemistry, Faculty of Science and Agriculture, University of Fort Hare, Alice, South Africa.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Hybrid Compounds Containing Carvacrol Scaffold:
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Hybrid Compounds Containing Carvacrol Scaffold:
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antifongiques › Hybrid Compounds Containing Carvacrol Scaffold:
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Hybrid Compounds Containing Carvacrol Scaffold:
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Hybrid Compounds Containing Carvacrol Scaffold:
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Monoterpènes › Cymènes › Hybrid Compounds Containing Carvacrol Scaffold:
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Hybrid Compounds Containing Carvacrol Scaffold:
questionsmedicales.fr › Lipides › Huiles › Huile essentielle › Hybrid Compounds Containing Carvacrol Scaffold: