Mixed in chains: NEDD8 polymers in the Protein Quality Control system.

Ubiquitins / metabolism Polymers Ubiquitin / metabolism Cullin Proteins / metabolism Ubiquitin-Protein Ligases / metabolism
Canonical/atypical NEDDylation NEDD8 polymers Protein Quality Control Proteostasis

Journal

Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332

Informations de publication

Date de publication:
12 2022
Historique:
received: 26 10 2021
revised: 11 01 2022
accepted: 14 01 2022
pubmed: 27 1 2022
medline: 23 11 2022
entrez: 26 1 2022
Statut: ppublish

Résumé

Post-translational modification of proteins with the Ubiquitin-like molecule NEDD8 is a critical regulatory mechanism for several biological processes and a potential target for therapeutic intervention. The role of NEDD8 has been mainly characterised through its modification as single moiety on the cullin family of proteins and control of Cullin-Ring-Ligases, but also on non-cullin substrates. In addition to monoNEDDylation, recent studies have now revealed that NEDD8 can also generate diverse polymers. This is either through modification of the 9 available lysines in NEDD8 and the formation of polyNEDD8 chains, or NEDDylation of Ubiquitin and SUMO-2 for the generation of hybrid NEDD8 chains. Here, we review recent findings that characterise the formation of NEDD8 polymers under distinct modes of protein NEDDylation (canonical/atypical) and their potential role as regulatory signals of the proteotoxic stress response and the Protein Quality Control system.

Identifiants

DOI: 10.1016/j.semcdb.2022.01.005 PMID: 35078718
pubmed: 35078718
pii: S1084-9521(22)00013-1
doi: 10.1016/j.semcdb.2022.01.005
pii:
doi:

Substances chimiques

Ubiquitins 0
Polymers 0
Ubiquitin 0
Cullin Proteins 0
Ubiquitin-Protein Ligases EC 2.3.2.27

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

27-37

Informations de copyright

Copyright © 2022. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declarations of interest None.

Auteurs

Igor Meszka (I)

CRBM, Univ. Montpellier, CNRS, Montpellier, France.

Jolanta Polanowska (J)

CRBM, Univ. Montpellier, CNRS, Montpellier, France.

Dimitris P Xirodimas (DP)

CRBM, Univ. Montpellier, CNRS, Montpellier, France. Electronic address: dimitris.xirodimas@crbm.cnrs.fr.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Ubiquitines › Mixed in chains: NEDD8 polymers in the Protein...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Mixed in chains: NEDD8 polymers in the Protein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Ubiquitines › Ubiquitine › Mixed in chains: NEDD8 polymers in the Protein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Cullines › Mixed in chains: NEDD8 polymers in the Protein...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › Mixed in chains: NEDD8 polymers in the Protein...