µCT to quantify muco-obstructive lung disease and effects of neutrophil elastase knockout in mice.

Animals Disease Models, Animal Epithelial Sodium Channels / genetics Leukocyte Elastase / genetics Lung / pathology Lung Diseases, Obstructive / pathology Mice Mice, Knockout Mice, Transgenic
lung imaging microscopic computed tomography mucin hypersecretion muco-obstructive lung disease transgenic mouse model

Journal

American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229

Informations de publication

Date de publication:
01 03 2022
Historique:
pubmed: 27 1 2022
medline: 3 5 2022
entrez: 26 1 2022
Statut: ppublish

Résumé

Muco-obstructive lung diseases are characterized by airway obstruction and hyperinflation, which can be quantified by imaging. Our aim was to evaluate µCT for longitudinal quantification of muco-obstructive lung disease in β-epithelial Na

Identifiants

DOI: 10.1152/ajplung.00341.2021 PMID: 35080183
pubmed: 35080183
doi: 10.1152/ajplung.00341.2021
doi:

Substances chimiques

Epithelial Sodium Channels 0
Leukocyte Elastase EC 3.4.21.37

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

L401-L411

Auteurs

Lin Zhu (L)

Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany.
Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at the University Hospital of Heidelberg, Heidelberg, Germany.
Department of Radiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
ORCID: 0000-0003-0322-9321

Julia Duerr (J)

Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Department of Translational Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
German Center for Lung Research (DZL), Berlin, Germany.
ORCID: 0000-0002-4862-9487

Zhe Zhou-Suckow (Z)

Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Department of Translational Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.

Willi Wagner (W)

Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany.
Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at the University Hospital of Heidelberg, Heidelberg, Germany.

Oliver Weinheimer (O)

Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany.
Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at the University Hospital of Heidelberg, Heidelberg, Germany.

Johanna Salomon (J)

Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Department of Translational Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.

Dominik Leitz (D)

Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Department of Translational Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
German Center for Lung Research (DZL), Berlin, Germany.

Philip Konietzke (P)

Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany.
Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at the University Hospital of Heidelberg, Heidelberg, Germany.

Hong Yu (H)

Department of Radiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Maximilian Ackermann (M)

Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Institute of Pathology and Department of Molecular Pathology, Helios University Clinic Wuppertal, University of Witten-Herdecke, Wuppertal, Germany.

Wolfram Stiller (W)

Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany.
Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.

Hans-Ulrich Kauczor (HU)

Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany.
Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at the University Hospital of Heidelberg, Heidelberg, Germany.

Marcus A Mall (MA)

Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Department of Translational Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
German Center for Lung Research (DZL), Berlin, Germany.
Berlin Institute of Health, Berlin, Germany.

Mark O Wielpütz (MO)

Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany.
Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at the University Hospital of Heidelberg, Heidelberg, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › µCT to quantify muco-obstructive lung disease...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › µCT to quantify muco-obstructive lung disease...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux sodiques › Canaux sodium épithéliaux › µCT to quantify muco-obstructive lung disease...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Pancreatic elastase › Leukocyte elastase › µCT to quantify muco-obstructive lung disease...
questionsmedicales.fr › Appareil respiratoire › Poumon › µCT to quantify muco-obstructive lung disease...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Bronchopneumopathies obstructives › µCT to quantify muco-obstructive lung disease...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › µCT to quantify muco-obstructive lung disease...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › µCT to quantify muco-obstructive lung disease...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › µCT to quantify muco-obstructive lung disease...