Association between childhood maltreatment and the clinical course of bipolar disorders: A survival analysis of mood recurrences.
bipolar disorder
childhood maltreatment
childhood trauma
mood recurrence
physical abuse
Journal
Acta psychiatrica Scandinavica
ISSN: 1600-0447
Titre abrégé: Acta Psychiatr Scand
Pays: United States
ID NLM: 0370364
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
revised:
08
01
2022
received:
18
10
2021
accepted:
16
01
2022
pubmed:
27
1
2022
medline:
3
5
2022
entrez:
26
1
2022
Statut:
ppublish
Résumé
Childhood maltreatment, also referred as childhood trauma, increases the severity of bipolar disorders (BD). Childhood maltreatment has been associated with more frequent mood recurrences, however, mostly in retrospective studies. Since scarce, further prospective studies are required to identify whether childhood maltreatment may be associated with the time to recurrence in BD. Individuals with BD (N = 2008) were assessed clinically and for childhood maltreatment at baseline, and followed up for two years. The cumulative probability of mood recurrence over time was estimated with the Turnbull's extension of the Kaplan-Meier analysis for interval-censored data, including childhood maltreatment as a whole, and then maltreatment subtypes as predictors. Analyses were adjusted for potential confounding factors. The median duration of follow-up was 22.3 months (IQR:12.0-24.8). Univariable analyses showed associations between childhood maltreatment, in particular all types of abuses (emotional, physical, and sexual) or emotional neglect, and a shorter time to recurrence (all p < 0.001). When including potential confounders into the multivariable models, the time to mood recurrence was associated with multiple/severe childhood maltreatment (i.e., total score above the 75th percentile) (HR = 1.32 95%CI (1.11-1.57), p = 0.002), and more specifically with moderate/severe physical abuse (HR = 1.44 95%CI(1.21-1.73), p < 0.0001). Living alone, lifetime anxiety disorders, lifetime number of mood episodes, baseline depressive and (hypo)manic symptoms, and baseline use of atypical antipsychotics were also associated with the time to recurrence. In addition to typical predictors of mood recurrences, an exposure to multiple/severe forms of childhood maltreatment, and more specifically to moderate to severe physical abuse, may increase the risk for a mood recurrence in BD. This leads to the recommendations of more scrutiny and denser follow-up of the individuals having been exposed to such early-life stressors.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
373-383Informations de copyright
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
McIntyre RS, Berk M, Brietzke E, et al. Bipolar disorders. Lancet. 2020;5(396):1841-1856.
Etain B, Aas M. Childhood maltreatment in bipolar disorders. Curr Top Behav Neurosci. 2020;48:277-301.
Etain B, Henry C, Bellivier F, Mathieu F, Leboyer M. Beyond genetics: childhood affective trauma in bipolar disorder. Bipolar Disord. 2008;10:867-876.
Nemeroff CB. Paradise lost: the neurobiological and clinical consequences of child abuse and neglect. Neuron. 2016;2(89):892-909.
Rodriguez V, Alameda L, Trotta G, et al. Environmental risk factors in bipolar disorder and psychotic depression: a systematic review and meta-analysis of prospective studies. Schizophr Bull. 2021;8(47):959-974.
Carr CP, Martins CM, Stingel AM, Lemgruber VB, Juruena MF. The role of early life stress in adult psychiatric disorders: a systematic review according to childhood trauma subtypes. J Nerv Ment Dis. 2013;201:1007-1020.
Etain B, Mathieu F, Henry C, et al. Preferential association between childhood emotional abuse and bipolar disorder. J Trauma Stress. 2010;23:376-383.
Palmier-Claus JE, Berry K, Bucci S, Mansell W, Varese F. Relationship between childhood adversity and bipolar affective disorder: systematic review and meta-analysis. Br J Psychiatry. 2016;209:454-459.
Cakir S, Tasdelen Durak R, Ozyildirim I, Ince E, Sar V. Childhood trauma and treatment outcome in bipolar disorder. J Trauma Dissociation. 2016;17(4):397-409.
Aas M, Etain B, Bellivier F, et al. Additive effects of childhood abuse and cannabis abuse on clinical expressions of bipolar disorders. Psychol Med. 2014;44:1653-1662.
Etain B, Aas M, Andreassen OA, et al. Childhood trauma is associated with severe clinical characteristics of bipolar disorders. J Clin Psychiatry. 2013;74:991-998.
Etain B, Lajnef M, Brichant-Petitjean C, et al. Childhood trauma and mixed episodes are associated with poor response to lithium in bipolar disorders. Acta Psychiatr Scand. 2017;135:319-327.
Aas M, Henry C, Bellivier F, et al. Affective lability mediates the association between childhood trauma and suicide attempts, mixed episodes and co-morbid anxiety disorders in bipolar disorders. Psychol Med. 2017;47:902-912.
Post RM, Altshuler L, Leverich GS, et al. Relationship of clinical course of illness variables to medical comorbidities in 900 adult outpatients with bipolar disorder. Compr Psychiatry. 2015;56:21-28.
Post RM, Altshuler LL, Kupka R, et al. Verbal abuse, like physical and sexual abuse, in childhood is associated with an earlier onset and more difficult course of bipolar disorder. Bipolar Disord. 2015;17:323-330.
Duarte D, Belzeaux R, Etain B, et al. Childhood-maltreatment subtypes in bipolar patients with suicidal behavior: systematic review and meta-analysis. Braz. J Psychiatry. 2020;42(5):558-567.
Watson S, Gallagher P, Dougall D, et al. Childhood trauma in bipolar disorder. Aust N Z J Psychiatry. 2014;48:564-570.
Agnew-Blais J, Danese A. Childhood maltreatment and unfavourable clinical outcomes in bipolar disorder: a systematic review and meta-analysis. Lancet Psychiatry. 2016;3:342-349.
Brown GR, McBride L, Bauer MS, Williford WO. COOPERATIVE STUDIES PROGRAM 430 STUDY T. Impact of childhood abuse on the course of bipolar disorder: a replication study in U.S. veterans. J Affect Disord. 2005;89:57-67.
Neria Y, Bromet EJ, Carlson GA, Naz B. Assaultive trauma and illness course in psychotic bipolar disorder: findings from the Suffolk county mental health project. Acta Psychiatr Scand. 2005;111:380-383.
Werbeloff N, Hilge Thygesen J, Hayes JF, Viding EM, Johnson S, Osborn DPJ. Childhood sexual abuse in patients with severe mental Illness: demographic, clinical and functional correlates. Acta Psychiatr Scand. 2021;143:495-502.
Cho Y, Kim D, Kim S-H. Prevalence and clinical correlates of childhood trauma among inpatients diagnosed with bipolar disorder: a matched comparison with schizophrenia. Psychosis. 2021;13(1):13-23.
Nolen WA, Luckenbaugh DA, Altshuler LL, et al. Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network. Am J Psychiatry. 2004;161:1447-1454.
Dienes KA, Hammen C, Henry RM, Cohen AN, Daley SE. The stress sensitization hypothesis: understanding the course of bipolar disorder. J Affect Disord. 2006;95:43-49.
Henry C, Etain B, Mathieu F, et al. A French network of bipolar expert centres: a model to close the gap between evidence-based medicine and routine practice. J Affect Disord. 2011;131:358-363.
First M, Sptzer R, Gibbon M, William J. Structured clinical interview for DSM-IV axis I disorders-patient edition (SCID-I/P). New York State Psychiatric Institute; 1995.
Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry J Mental Sci. 1979;1979(134):382-389.
Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry J Mental Sci. 1978;1978(133):429-435.
Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28:193-213.
Bernstein DP, Fink L, Handelsman L, et al. Initial reliability and validity of a new retrospective measure of child abuse and neglect. Am J Psychiatry. 1994;151:1132-1136.
AMERICAN PSYCHIATRIC ASSOCIATION. Diagnostic and statistical manual of mental disorders. Fourth Edition; 1994.
Etain B, Bellivier F, Olie E, et al. Clinical predictors of recurrences in bipolar disorders type 1 and 2: A FACE-BD longitudinal study. J Psychiatr Res. 2021;134:129-137.
Tohen M, Frank E, Bowden CL, et al. The international society for bipolar disorders (ISBD) Task Force report on the nomenclature of course and outcome in bipolar disorders. Bipolar Disord. 2009;11:453-473.
Vazquez GH, Holtzman JN, Lolich M, Ketter TA, Baldessarini RJ. Recurrence rates in bipolar disorder: systematic comparison of long-term prospective, naturalistic studies versus randomized controlled trials. Eur Neuropsychopharmacol J Eur Coll Neuropsychopharmacol. 2015;25:1501-1512.
Radua J, Grunze H, Amann BL. Meta-analysis of the risk of subsequent mood episodes in bipolar disorder. Psychother Psychosom. 2017;86:90-98.
Opel N, Redlich R, Dohm K, et al. Mediation of the influence of childhood maltreatment on depression relapse by cortical structure: a 2-year longitudinal observational study. Lancet Psychiatry. 2019;6:318-326.
Harkness KL, Bagby RM, Kennedy SH. Childhood maltreatment and differential treatment response and recurrence in adult major depressive disorder. J Consult Clin Psychol. 2012;80:342-353.
Buckman J, Underwood A, Clarke K, et al. Risk factors for relapse and recurrence of depression in adults and how they operate: a four-phase systematic review and meta-synthesis. Clin Psychol Rev. 2018;64:13-38.
Petros N, Foglia E, Klamerus E, Beards S, Murray RM, Bhattacharyya S. Impact of childhood trauma on risk of relapse requiring psychiatric hospital admission for psychosis. Br J Psychiatry. 2016;209:169-170.
Nestsiarovich A, Gaudiot CES, Baldessarini RJ, Vieta E, Zhu Y, Tohen M. Preventing new episodes of bipolar disorder in adults: systematic review and meta-analysis of randomized controlled trials. Eur Neuropsychopharmacol J Eur Coll Neuropsychopharmacol. 2021;54:75-89.
Georgieva S, Tomas JM, Navarro-Pérez JJ. Systematic review and critical appraisal of childhood trauma questionnaire - short form (CTQ-SF). Child Abuse Negl. 2021;120(105223):105223.
Dalgleish T, Werner-Seidler A. Disruptions in autobiographical memory processing in depression and the emergence of memory therapeutics. Trends Cogn Sci. 2014;18:596-604.
Baldwin JR, Reuben A, Newbury JB, Danese A. Agreement between prospective and retrospective measures of childhood maltreatment: a systematic review and meta-analysis. JAMA Psychiatry. 2019;1(76):584-593.
Shannon C, Hanna D, Tumelty L, et al. Reliability of reports of childhood trauma in bipolar disorder: a test-retest study over 18 months. J Trauma Dissociation. 2016;17(4):511-519.
Church C, Andreassen OA, Lorentzen S, Melle I, Aas M. Childhood trauma and minimization/denial in people with and without a severe mental disorder. Front Psychol. 2017;8:1276.
Gayer-Anderson C, Reininghaus U, Paetzold I, et al. A comparison between self-report and interviewer-rated retrospective reports of childhood abuse among individuals with first-episode psychosis and population-based controls. J Psychiatr Res. 2020;123:145-150.
Alameda L, Ferrari C, Baumann PS, Gholam-Rezaee M, Do KQ, Conus P. Childhood sexual and physical abuse: age at exposure modulates impact on functional outcome in early psychosis patients. Psychol Med. 2015;45:2727-2736.
MacDonald K, Thomas ML, Sciolla AF, et al. Minimization of childhood maltreatment is common and consequential: results from a large, multinational sample using the childhood trauma questionnaire. PLoS One. 2016;11(1):e0146058.
Begemann MJH, Schutte MJL, van Dellen E, et al. Childhood trauma is associated with reduced frontal gray matter volume: a large transdiagnostic structural MRI study. Psychol Med. 2021;3:1-9.
Hosang GM, Fisher HL, Hodgson K, Maughan B, Farmer AE. Childhood maltreatment and adult medical morbidity in mood disorders: comparison of unipolar depression with bipolar disorder. Br J Psychiatry. 2018;213:645-653.
Hosang GM, Fisher HL, Uher R, et al. Childhood maltreatment and the medical morbidity in bipolar disorder: a case-control study. Int J Bipolar Disord. 2017;7(5):30.
Etain B, Lajnef M, Henry C, et al. Childhood trauma, dimensions of psychopathology and the clinical expression of bipolar disorders: a pathway analysis. J Psychiatr Res. 2017;95:37-45.
Marwaha S, Briley PM, Perry A, et al. Explaining why childhood abuse is a risk factor for poorer clinical course in bipolar disorder: a path analysis of 923 people with bipolar I disorder. Psychol Med. 2020;50:2346-2354.
Henry C, Van den Bulke D, Bellivier F, et al. Affective lability and affect intensity as core dimensions of bipolar disorders during euthymic period. Psychiatry Res. 2008;30(159):1-6.
Grillault Laroche D, Curis E, Bellivier F, et al. Network of co-expressed circadian genes, childhood maltreatment and sleep quality in bipolar disorders. Chronobiol Int. 2021;38:986-993.
Grillault Laroche D, Curis E, Bellivier F, et al. Childhood maltreatment and HPA axis gene expression in bipolar disorders: a gene network analysis. Psychoneuroendocrinology. 2020;120(104753).
Aas M, Dieset I, Mørch R, et al. Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders. Schizophr Res. 2019;205:45-50.
Aas M, Henry C, Andreassen OA, Bellivier F, Melle I, Etain B. The role of childhood trauma in bipolar disorders . Int J Bipolar Disord. 2016;4:2.
Tursich M, Neufeld RWJ, Frewen PA, et al. Association of trauma exposure with proinflammatory activity: a transdiagnostic meta-analysis. Transl. Psychiatry. 2014;22(4):e413.
Baumeister D, Akhtar R, Ciufolini S, Pariante CM, Mondelli V. Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-alpha. Mol Psychiatry. 2016;21:642-649.
Fries GR, Pfaffenseller B, Stertz L, et al. Staging and neuroprogression in bipolar disorder. Curr Psychiatry Rep. 2012;14:667-675.
Berk M, Kapczinski F, Andreazza AC, et al. Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev. 2011;35:804-817.
Cascino G, D'Agostino G, Monteleone AM, et al. Childhood maltreatment and clinical response to mood stabilizers in patients with bipolar disorder. Hum Psychopharmacol. 2021;36(4):e2783.
Perlini C, Donisi V, Rossetti MG, Moltrasio C, Bellani M, Brambilla P. The potential role of EMDR on trauma in affective disorders: a narrative review. J Affect Disord. 2020;15(269):1-11.
McIntyre RS, Subramaniapillai M, Lee Y, et al. Efficacy of adjunctive infliximab vs placebo in the treatment of adults with bipolar I/II depression: a randomized clinical trial. JAMA Psychiatry. 2019;1(76):783-790.