Inherited defects in the complement system.

Complement System Proteins / genetics Humans
alternative classical complement deficiency inherited lectin pathways system

Journal

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
ISSN: 1399-3038
Titre abrégé: Pediatr Allergy Immunol
Pays: England
ID NLM: 9106718

Informations de publication

Date de publication:
01 2022
Historique:
revised: 28 07 2021
received: 17 06 2021
accepted: 06 08 2021
entrez: 26 1 2022
pubmed: 27 1 2022
medline: 1 4 2022
Statut: ppublish

Résumé

The complement system plays an essential role in both innate and adaptive immune responses. Any dysregulation in this system can disturb normal host defense and alter inflammatory response leading to both infections and autoimmune diseases. The complement system can be activated through three different pathways. Inherited complement deficiencies have been described for all complement components and their regulators. Despite being rare diseases, complement deficiencies are often severe, with a frequent onset during childhood. We provide an overview of clinical disorders related to these disorders and describe current diagnostic strategies required for their comprehensive characterization and management.

Identifiants

DOI: 10.1111/pai.13635 PMID: 35080299 PMC: PMC9544610
pubmed: 35080299
doi: 10.1111/pai.13635
pmc: PMC9544610
doi:

Substances chimiques

Complement System Proteins 9007-36-7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

73-76

Informations de copyright

© 2022 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

Références

Mol Immunol. 2011 Aug;48(14):1643-55
pubmed: 21624663
Mol Immunol. 2014 Oct;61(2):110-7
pubmed: 25037634
Pediatr Allergy Immunol. 2022 Jan;33 Suppl 27:73-76
pubmed: 35080299
JAMA. 2001 Mar 14;285(10):1316-21
pubmed: 11255386
Allergy. 2018 Aug;73(8):1575-1596
pubmed: 29318628
Clin Lab Med. 2019 Dec;39(4):579-590
pubmed: 31668271
Mol Immunol. 2019 Oct;114:299-311
pubmed: 31421540
J Clin Immunol. 2020 May;40(4):576-591
pubmed: 32064578
Front Immunol. 2016 Feb 24;7:55
pubmed: 26941740
J Clin Immunol. 2015 Feb;35(2):199-205
pubmed: 25663093

Auteurs

Lucia Leonardi (L)

Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
ORCID: 0000-0002-2554-1263

Francesco La Torre (F)

Department of Pediatrics, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy.
ORCID: 0000-0002-5235-2900

Annarosa Soresina (A)

Unit of Pediatric Immunology, Pediatrics Clinic, University of Brescia, ASST Spedali Civili Brescia, Brescia, Italy.

Silvia Federici (S)

Division of Rheumatology, IRCCS, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
ORCID: 0000-0001-7780-6430

Caterina Cancrini (C)

Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Academic Department of Pediatrics, Immune, and Infectious Diseases Division, Research Unit of Primary Immunodeficiencies, Bambino Gesù, Children's Hospital, IRCCS, Rome, Italy.
ORCID: 0000-0001-8410-9617

Riccardo Castagnoli (R)

Department of Pediatrics, Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
ORCID: 0000-0003-0029-9383

Bianca Laura Cinicola (BL)

Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
ORCID: 0000-0003-1268-5038

Stefania Corrente (S)

Division of Pediatrics, S. Camillo-Forlanini Hospital, Rome, Italy.

Giuliana Giardino (G)

Pediatric Section, Department of Translational Medical Sciences, Federico II University, Naples, Italy.
ORCID: 0000-0002-0621-9527

Vassilios Lougaris (V)

Department of Clinical and Experimental Sciences, Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, University of Brescia and ASST-Spedali Civili di Brescia, Brescia, Italy.
ORCID: 0000-0003-2303-9533

Stefano Volpi (S)

Center for Autoinflammatory Diseases and Immunodeficiency, IRCCS Istituto Giannina Gaslini, Università degli Studi di Genova, Genoa, Italy.
ORCID: 0000-0002-7129-868X

Gian Luigi Marseglia (GL)

Department of Pediatrics, Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
ORCID: 0000-0003-3662-0159

Fabio Cardinale (F)

Department of Pediatrics, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy.
ORCID: 0000-0002-6774-6152

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéines du système du complément › Inherited defects in the complement system.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inherited defects in the complement system.