Vitamin D
Adolescents
Bone density
Calcium carbonate
Gut microbiome
HIV
Immune function
Pubertal delay
Stunting
Vitamin D3
Journal
Trials
ISSN: 1745-6215
Titre abrégé: Trials
Pays: England
ID NLM: 101263253
Informations de publication
Date de publication:
26 Jan 2022
26 Jan 2022
Historique:
received:
14
06
2021
accepted:
26
12
2021
entrez:
27
1
2022
pubmed:
28
1
2022
medline:
29
1
2022
Statut:
epublish
Résumé
Of the 2 million children living with HIV globally, 90% live in sub-Saharan Africa. Despite antiretroviral therapy, longstanding HIV infection is associated with several chronic complications in children including growth failure, particularly stunting and delayed puberty. Vitamin D deficiency, which is highly prevalent among children living with HIV in sub-Saharan Africa, has a further adverse impact on bone health. This trial aims to establish whether supplementation with vitamin D We will conduct an individually randomised, double-blinded, placebo-controlled trial of weekly high-dose vitamin D This is the largest trial to date of vitamin D supplementation in children living with HIV. Intervening to address deficits in bone accrual in childhood is critical for optimising adolescent and early adult bone health and prevention of later adult osteoporotic fractures. Trial results will draw attention to the need to screen for and treat long-term comorbidities in children living with HIV in resource-limited settings. Pan African Clinical Trials Registry PACTR20200989766029 . Registered on 3 September 2020.
Sections du résumé
BACKGROUND
BACKGROUND
Of the 2 million children living with HIV globally, 90% live in sub-Saharan Africa. Despite antiretroviral therapy, longstanding HIV infection is associated with several chronic complications in children including growth failure, particularly stunting and delayed puberty. Vitamin D deficiency, which is highly prevalent among children living with HIV in sub-Saharan Africa, has a further adverse impact on bone health. This trial aims to establish whether supplementation with vitamin D
METHODS/DESIGN
METHODS
We will conduct an individually randomised, double-blinded, placebo-controlled trial of weekly high-dose vitamin D
DISCUSSION
CONCLUSIONS
This is the largest trial to date of vitamin D supplementation in children living with HIV. Intervening to address deficits in bone accrual in childhood is critical for optimising adolescent and early adult bone health and prevention of later adult osteoporotic fractures. Trial results will draw attention to the need to screen for and treat long-term comorbidities in children living with HIV in resource-limited settings.
TRIAL REGISTRATION
BACKGROUND
Pan African Clinical Trials Registry PACTR20200989766029 . Registered on 3 September 2020.
Identifiants
pubmed: 35081986
doi: 10.1186/s13063-021-05985-0
pii: 10.1186/s13063-021-05985-0
pmc: PMC8790223
doi:
Substances chimiques
Vitamin D
1406-16-2
Cholecalciferol
1C6V77QF41
Calcium Carbonate
H0G9379FGK
Types de publication
Clinical Trial Protocol
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
78Subventions
Organisme : Wellcome Trust
ID : 206316/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R010161/1
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
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