Tumour infiltrating lymphocyte density differs by meningioma type and is associated with prognosis in atypical meningioma.

Forkhead Transcription Factors Humans Lymphocytes, Tumor-Infiltrating Meningeal Neoplasms / pathology Meningioma / pathology Prognosis Programmed Cell Death 1 Receptor
Meningioma immune lymphocyte microenvironment prognosis recurrence

Journal

Pathology
ISSN: 1465-3931
Titre abrégé: Pathology
Pays: England
ID NLM: 0175411

Informations de publication

Date de publication:
Jun 2022
Historique:
received: 22 07 2021
revised: 01 10 2021
accepted: 08 10 2021
pubmed: 28 1 2022
medline: 7 6 2022
entrez: 27 1 2022
Statut: ppublish

Résumé

Tumour infiltrating lymphocyte (TIL) density is prognostically significant in various tumours, but few studies have investigated its significance in meningioma. This study aimed to investigate how TIL density differs by meningioma histology and whether it is a predictor of meningioma recurrence. We studied CD3, CD8, CD4, FOXP3 and PD-1 positive (+) TIL density in a continuous cohort of 476 meningiomas resected at Auckland Hospital between 2002 and 2011 using tissue microarrays and computer assisted image analysis. TILs were identified in all meningiomas except one (median CD3+ TIL density across entire cohort 53.0 cells/mm

Identifiants

DOI: 10.1016/j.pathol.2021.10.002 PMID: 35082053
pubmed: 35082053
pii: S0031-3025(21)00541-9
doi: 10.1016/j.pathol.2021.10.002
pii:
doi:

Substances chimiques

Forkhead Transcription Factors 0
Programmed Cell Death 1 Receptor 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

417-424

Informations de copyright

Copyright © 2021 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.

Auteurs

Clinton P Turner (CP)

Department of Anatomical Pathology, LabPlus, Auckland City Hospital, Auckland, New Zealand; Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. Electronic address: clintont@adhb.govt.nz.

Jessica McLay (J)

Department of Statistics, Faculty of Science, University of Auckland, Auckland, New Zealand.

Ian F Hermans (IF)

Malaghan Institute of Medical Research, Wellington, New Zealand.

Jason Correia (J)

Department of Neurosurgery, Auckland City Hospital, Auckland, New Zealand.

Arnold Bok (A)

Department of Neurosurgery, Auckland City Hospital, Auckland, New Zealand.

Nasim Mehrabi (N)

Centre for Brain Research, Department of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Stephen Gock (S)

Department of Radiology, Auckland City Hospital, Auckland, New Zealand.

Blake Highet (B)

Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Maurice A Curtis (MA)

Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Michael Dragunow (M)

Centre for Brain Research, Department of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. Electronic address: m.dragunow@auckland.ac.nz.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Tumour infiltrating lymphocyte density differs...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tumour infiltrating lymphocyte density differs...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes TIL › Tumour infiltrating lymphocyte density differs...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs des méninges › Tumour infiltrating lymphocyte density differs...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs des méninges › Méningiome › Tumour infiltrating lymphocyte density differs...
questionsmedicales.fr › Diagnostic › Pronostic › Tumour infiltrating lymphocyte density differs...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Récepteur-1 de mort cellulaire programmée › Tumour infiltrating lymphocyte density differs...