Scorpion Venom Antimicrobial Peptides Induce Caspase-1 Dependant Pyroptotic Cell Death.
Antimicrobial peptides
IL-1b
Smp24
Smp43
caspase-1
cell death
pyroptosis
scorpio maurus palmatus
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
10
2021
accepted:
13
12
2021
entrez:
27
1
2022
pubmed:
28
1
2022
medline:
28
1
2022
Statut:
epublish
Résumé
Within the last decade, several peptides have been identified according to their ability to inhibit the growth of microbial pathogens. These antimicrobial peptides (AMPs) are a part of the innate immune system of all living organisms. Many studies on their effects on prokaryotic microorganisms have been reported; some of these peptides have cytotoxic properties although the molecular mechanisms underlying their activity on eukaryotic cells remain poorly understood. Smp24 and Smp43 are novel cationic AMPs which were identified from the venom of the Egyptian scorpion
Identifiants
pubmed: 35082671
doi: 10.3389/fphar.2021.788874
pii: 788874
pmc: PMC8784870
doi:
Types de publication
Journal Article
Langues
eng
Pagination
788874Informations de copyright
Copyright © 2022 Elrayess, Mohallal, Mobarak, Ebaid, Haywood-Small, Miller, Strong and Abdel-Rahman.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor declared a past collaboration with one of the authors MA-R.
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