Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish.
RNA-seq
addiction
amphetamine
behavior
developmental exposure
nicotine
oxycodone
zebrafish
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
10
2021
accepted:
29
11
2021
entrez:
27
1
2022
pubmed:
28
1
2022
medline:
28
1
2022
Statut:
epublish
Résumé
Developmental consequences of prenatal drug exposure have been reported in many human cohorts and animal studies. The long-lasting impact on the offspring-including motor and cognitive impairments, cranial and cardiac anomalies and increased prevalence of ADHD-is a socioeconomic burden worldwide. Identifying the molecular changes leading to developmental consequences could help ameliorate the deficits and limit the impact. In this study, we have used zebrafish, a well-established behavioral and genetic model with conserved drug response and reward pathways, to identify changes in behavior and cellular pathways in response to developmental exposure to amphetamine, nicotine or oxycodone. In the presence of the drug, exposed animals showed altered behavior, consistent with effects seen in mammalian systems, including impaired locomotion and altered habituation to acoustic startle. Differences in responses seen following acute and chronic exposure suggest adaptation to the presence of the drug. Transcriptomic analysis of exposed larvae revealed differential expression of numerous genes and alterations in many pathways, including those related to cell death, immunity and circadian rhythm regulation. Differential expression of circadian rhythm genes did not correlate with behavioral changes in the larvae, however, two of the circadian genes,
Identifiants
pubmed: 35082702
doi: 10.3389/fpsyt.2021.795175
pmc: PMC8785235
doi:
Types de publication
Journal Article
Langues
eng
Pagination
795175Subventions
Organisme : NIDA NIH HHS
ID : U01 DA044400
Pays : United States
Informations de copyright
Copyright © 2022 Mech, Merteroglu, Sealy, Teh, White, Havelange, Brennan and Busch-Nentwich.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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