Hemodynamics and Metabolic Parameters in Normothermic Kidney Preservation Are Linked With Donor Factors, Perfusate Cells, and Cytokines.
ex-situ perfusion
kidney transplantation
normothermic
organ preservation
urine recirculation
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2021
2021
Historique:
received:
24
10
2021
accepted:
08
12
2021
entrez:
27
1
2022
pubmed:
28
1
2022
medline:
28
1
2022
Statut:
epublish
Résumé
Kidney transplantation is the best renal-replacement option for most patients with end-stage renal disease. Normothermic machine preservation (NMP) of the kidney has been studied extensively during the last two decades and implemented in clinical trials. Biomarker research led to success in identifying molecules with diagnostic, predictive and therapeutic properties in chronic kidney disease. However, perfusate biomarkers and potential predictive mechanisms in NMP have not been identified yet. Twelve discarded human kidneys (
Identifiants
pubmed: 35083252
doi: 10.3389/fmed.2021.801098
pmc: PMC8784871
doi:
Types de publication
Journal Article
Langues
eng
Pagination
801098Informations de copyright
Copyright © 2022 Weissenbacher, Stone, Lo Faro, Hunter, Ploeg, Coussios, Fildes and Friend.
Déclaration de conflit d'intérêts
PF and CC are co-founders of OrganOx R Limited, receive consultancy payments as non-executive medical and technical directors of OrganOx R Limited, and are shareholders. JF is the Chief Scientific Officer of the ex-vivo Research Center CIC, but receives no payments and has no shares and is an executive director of Perfusion Biotechnology Limited. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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