Pathological manifestation of human endogenous retrovirus K in frontotemporal dementia.
HERV-K
HERV-W
TDP-43
amyotrophic lateral sclerosis
biomarker
brain
frontotemporal dementia
human endogenous retrovirus
motor neuron disease
serum
Journal
Communications medicine
ISSN: 2730-664X
Titre abrégé: Commun Med (Lond)
Pays: England
ID NLM: 9918250414506676
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
27
1
2022
pubmed:
28
1
2022
medline:
28
1
2022
Statut:
ppublish
Résumé
Behavioral variant frontotemporal dementia (bvFTD) is a common form of younger-onset dementia with a proportion of cases overlapping pathologically and genetically with amyotrophic lateral sclerosis (ALS). Previous studies have identified that the human endogenous retrovirus K (HERV-K) is elevated in ALS serum and is associated with ALS TDP-43 pathology. In contrast, little is known about HERV-K changes in bvFTD. Here, we investigated the possible role of HERV-K in bvFTD. We measured the HERV-K Here, we show that HERV-K These results suggest that manifestation of HERV-K is associated with bvFTD TDP-43 pathology. Analysis of HERV-K in bvFTD may provide insight into an unrecognized but targetable perturbed pathology.
Sections du résumé
BACKGROUND
Behavioral variant frontotemporal dementia (bvFTD) is a common form of younger-onset dementia with a proportion of cases overlapping pathologically and genetically with amyotrophic lateral sclerosis (ALS). Previous studies have identified that the human endogenous retrovirus K (HERV-K) is elevated in ALS serum and is associated with ALS TDP-43 pathology. In contrast, little is known about HERV-K changes in bvFTD. Here, we investigated the possible role of HERV-K in bvFTD.
METHODS
We measured the HERV-K
RESULTS
Here, we show that HERV-K
CONCLUSIONS
These results suggest that manifestation of HERV-K is associated with bvFTD TDP-43 pathology. Analysis of HERV-K in bvFTD may provide insight into an unrecognized but targetable perturbed pathology.
Identifiants
pubmed: 35083468
doi: 10.1038/s43856-021-00060-w
pmc: PMC8788987
mid: NIHMS1771496
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIAAA NIH HHS
ID : R28 AA012725
Pays : United States
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing interests.
Références
Antiviral Res. 2013 Aug;99(2):180-7
pubmed: 23707220
BMC Neurol. 2018 Jun 28;18(1):90
pubmed: 29954341
J Virol. 1995 Jun;69(6):3584-96
pubmed: 7745706
Nature. 2000 Feb 17;403(6771):785-9
pubmed: 10693809
Science. 2019 Feb 15;363(6428):
pubmed: 30765536
Acta Neuropathol. 2007 Jul;114(1):5-22
pubmed: 17579875
Brain. 2011 Sep;134(Pt 9):2582-94
pubmed: 21840887
Ann Neurol. 2001 Oct;50(4):434-42
pubmed: 11601494
J Biol Chem. 2011 Jan 14;286(2):1204-15
pubmed: 21051541
J Virol. 2014 Oct;88(19):11108-20
pubmed: 25056891
J Virol. 2014 Sep 1;88(17):9673-82
pubmed: 24920813
Lancet Neurol. 2016 Oct;15(11):1182-94
pubmed: 27647646
Amyotroph Lateral Scler Frontotemporal Degener. 2019 Nov;20(7-8):595-604
pubmed: 31284774
Sci Transl Med. 2015 Sep 30;7(307):307ra153
pubmed: 26424568
Cell Rep. 2018 Jun 5;23(10):2874-2880
pubmed: 29874575
J Neurol Neurosurg Psychiatry. 2012 Jan;83(1):102-8
pubmed: 21836033
JCI Insight. 2020 Apr 9;5(7):
pubmed: 32271161
J Neurochem. 2016 Aug;138 Suppl 1:32-53
pubmed: 27009575
Neurobiol Dis. 2016 Oct;94:226-36
pubmed: 27370226
Brain. 2011 Sep;134(Pt 9):2456-77
pubmed: 21810890
Retrovirology. 2017 Mar 22;14(1):21
pubmed: 28330477
J Gen Virol. 1999 Jan;80 ( Pt 1):255-260
pubmed: 9934709
J Neurol Neurosurg Psychiatry. 2021 Jan 13;:
pubmed: 33441385
Lancet Neurol. 2016 Mar;15(3):332-42
pubmed: 26822748
Nat Genet. 2008 May;40(5):572-4
pubmed: 18372902
PLoS One. 2014 Jul 02;9(7):e97984
pubmed: 24988390
Eur J Neurol. 2018 Aug;25(8):1076-e84
pubmed: 29603839
Lancet. 2015 Oct 24;386(10004):1672-82
pubmed: 26595641
Mol Neurobiol. 2018 Oct;55(10):7789-7801
pubmed: 29460270
Retrovirology. 2006 Oct 03;3:67
pubmed: 17018135
Neurology. 2016 Oct 25;87(17):1756-1762
pubmed: 27664983
Crit Rev Microbiol. 2018 Nov;44(6):715-738
pubmed: 30318978
Curr Biol. 2019 Oct 7;29(19):3135-3152.e4
pubmed: 31495585
Int J Mol Sci. 2019 Jul 29;20(15):
pubmed: 31362360
PLoS One. 2012;7(9):e44099
pubmed: 22957047
J Neurol Sci. 2021 Apr 15;423:117358
pubmed: 33653604
AIDS. 2007 Nov 30;21(18):2417-24
pubmed: 18025878
Neurology. 2002 Oct 8;59(7):1077-9
pubmed: 12370467
Front Aging Neurosci. 2018 Jan 30;10:11
pubmed: 29441012
EMBO J. 2001 Apr 2;20(7):1774-84
pubmed: 11285240
Neurol Genet. 2016 May 26;2(3):e80
pubmed: 27280171
Open AIDS J. 2015 Dec 07;9:112-22
pubmed: 26793281
Lancet. 2016 Aug 27;388(10047):919-31
pubmed: 26987909
Nat Rev Neurol. 2021 Feb;17(2):104-118
pubmed: 33340024
Front Microbiol. 2020 Jul 17;11:1690
pubmed: 32765477
Hum Mol Genet. 2017 May 1;26(9):1732-1746
pubmed: 28334913
Front Immunol. 2018 Sep 10;9:2039
pubmed: 30250470
Ann Neurol. 2011 Jan;69(1):141-51
pubmed: 21280084
Mob DNA. 2019 Jul 26;10:32
pubmed: 31372185
Neurol Clin. 2017 May;35(2):339-374
pubmed: 28410663
Lancet. 2011 Mar 12;377(9769):942-55
pubmed: 21296405
Acta Neuropathol. 2010 Jan;119(1):1-4
pubmed: 19924424
Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4894-9
pubmed: 15044706
Alzheimers Dement. 2012 Jan;8(1):1-13
pubmed: 22265587
Acta Neuropathol. 2012 Jan;123(1):1-11
pubmed: 22101365
Neurology. 2014 Nov 11;83(20):1812-8
pubmed: 25305153
Trends Mol Med. 2018 Apr;24(4):379-394
pubmed: 29551251
J Virol. 2016 Sep 29;90(20):9338-49
pubmed: 27512062
Amyotroph Lateral Scler. 2007 Apr;8(2):67-72
pubmed: 17453631
Science. 2006 Oct 6;314(5796):130-3
pubmed: 17023659
Clin Neurophysiol. 2020 Aug;131(8):1975-1978
pubmed: 32387049
Neurology. 2008 Jan 22;70(4):278-83
pubmed: 18209202