Comparison of acute myeloid leukemia and myelodysplastic syndromes with TP53 aberrations.
Acute myeloid leukemia
EAp53 and RFS score
Myelodysplastic syndromes
Stem cell disorder
TP53
Journal
Annals of hematology
ISSN: 1432-0584
Titre abrégé: Ann Hematol
Pays: Germany
ID NLM: 9107334
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
26
11
2021
accepted:
13
01
2022
pubmed:
28
1
2022
medline:
15
3
2022
entrez:
27
1
2022
Statut:
ppublish
Résumé
TP53 aberrations are found in approximately 10% of patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) and are considered early driver events affecting leukemia stem cells. In this study, we compared features of a total of 84 patients with these disorders seen at a tertiary cancer center. Clinical and cytogenetic characteristics as well as immunophenotypes of immature blast cells were similar between AML and MDS patients. Median overall survival (OS) was 226 days (95% confidence interval [CI], 131-300) for the entire cohort with an estimated 3-year OS rate of 11% (95% CI, 6-22). OS showed a significant difference between MDS (median, 345 days; 95% CI, 235-590) and AML patients (median, 91 days; 95% CI, 64-226) which is likely due to a different co-mutational pattern as revealed by next-generation sequencing. Transformation of TP53 aberrant MDS occurred in 60.5% of cases and substantially reduced their survival probability. Cox regression analysis revealed treatment class and TP53 variant allele frequency as prognostically relevant parameters but not the TP53-specific prognostic scores EAp53 and RFS. These data emphasize similarities between TP53 aberrant AML and MDS and support previous notions that they should be classified and treated as a distinct disorder.
Identifiants
pubmed: 35083527
doi: 10.1007/s00277-022-04766-2
pii: 10.1007/s00277-022-04766-2
pmc: PMC8913568
doi:
Substances chimiques
TP53 protein, human
0
Tumor Suppressor Protein p53
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
837-846Subventions
Organisme : Austrian Science Fund FWF
ID : P 31430
Pays : Austria
Informations de copyright
© 2022. The Author(s).
Références
Nat Rev Cancer. 2017 Jan;17(1):5-19
pubmed: 27834397
Blood. 2016 Nov 3;128(18):2270-2272
pubmed: 27621308
Front Oncol. 2020 Jan 22;9:1380
pubmed: 32038992
Stat Med. 1990 Jul;9(7):811-8
pubmed: 2218183
N Engl J Med. 2011 Jun 30;364(26):2496-506
pubmed: 21714648
Cancers (Basel). 2020 Mar 10;12(3):
pubmed: 32164171
Ann Hematol. 2020 Mar;99(3):653-655
pubmed: 32002654
Leukemia. 2019 Jan;33(1):64-74
pubmed: 29946192
Blood. 2015 Feb 26;125(9):1367-76
pubmed: 25550361
Haematologica. 2019 Mar;104(3):516-523
pubmed: 30309854
Am J Hematol. 2020 Jun 29;:
pubmed: 32602117
Genes Dev. 2010 Jul 1;24(13):1389-402
pubmed: 20595231
J Clin Oncol. 2021 May 10;39(14):1584-1594
pubmed: 33449813
Eur J Haematol. 2020 Nov;105(5):524-539
pubmed: 32621334
Br J Haematol. 2016 Mar;172(6):914-22
pubmed: 26771088
Cell Stem Cell. 2009 Jan 9;4(1):37-48
pubmed: 19128791
Cancer Cell. 2014 Jun 16;25(6):794-808
pubmed: 24835589
J Clin Oncol. 2021 May 10;39(14):1575-1583
pubmed: 33600210
Clin Cancer Res. 2020 Oct 15;26(20):5304-5309
pubmed: 32816950
Cell Biochem Funct. 2021 Mar;39(2):235-247
pubmed: 32996618
Leukemia. 2018 Dec;32(12):2546-2557
pubmed: 30275526
Cell. 2017 Sep 7;170(6):1062-1078
pubmed: 28886379
N Engl J Med. 2012 Mar 22;366(12):1090-8
pubmed: 22417201
N Engl J Med. 2016 Jun 9;374(23):2209-2221
pubmed: 27276561
Exp Hematol Oncol. 2020 Jan 6;9:2
pubmed: 31921515
Blood Adv. 2020 Oct 27;4(20):5011-5024
pubmed: 33057635
J Med Genet. 2012 Jul;49(7):422-8
pubmed: 22652532
Cancers (Basel). 2021 Oct 27;13(21):
pubmed: 34771553
Blood. 2018 Jun 28;131(26):2989-2992
pubmed: 29769261
Haematologica. 2018 Jan;103(1):e17-e20
pubmed: 29079594
Blood. 2016 May 19;127(20):2391-405
pubmed: 27069254
N Engl J Med. 2015 Sep 17;373(12):1136-52
pubmed: 26376137
Semin Hematol. 2015 Jul;52(3):150-64
pubmed: 26111462
Leukemia. 2019 Jul;33(7):1747-1758
pubmed: 30635634
Blood. 2017 May 4;129(18):2587-2591
pubmed: 28258055
Haematologica. 2020 Jan 31;105(2):375-386
pubmed: 31097632
Blood. 1992 Apr 15;79(8):1982-6
pubmed: 1562724
Nat Med. 2020 Oct;26(10):1549-1556
pubmed: 32747829
N Engl J Med. 2018 Sep 13;379(11):1028-1041
pubmed: 30207916
Nature. 2018 Jul;559(7714):400-404
pubmed: 29988082
Blood. 2020 Mar 12;135(11):791-803
pubmed: 31932844
N Engl J Med. 2020 Aug 13;383(7):617-629
pubmed: 32786187
Nat Med. 2019 Jan;25(1):103-110
pubmed: 30510255
Blood. 2015 Jul 2;126(1):9-16
pubmed: 25931582