Neuroinflammation PET imaging of the translocator protein (TSPO) in Alzheimer's disease: An update.
Alzheimer's disease
PET
TSPO
microglia
neuroinflammation
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
revised:
18
01
2022
received:
10
12
2021
accepted:
19
01
2022
pubmed:
28
1
2022
medline:
12
4
2022
entrez:
27
1
2022
Statut:
ppublish
Résumé
Neuroinflammation is a significant contributor to Alzheimer's disease (AD). Until now, PET imaging of the translocator protein (TSPO) has been widely used to depict the neuroimmune endophenotype of AD. The aim of this review was to provide an update to the results from 2018 and to advance the characterization of the biological basis of TSPO imaging in AD by re-examining TSPO function and expression and the methodological aspects of interest. Although the biological basis of the TSPO PET signal is obviously related to microglia and astrocytes in AD, the observed process remains uncertain and might not be directly related to neuroinflammation. Further studies are required to re-examine the cellular significance underlying a variation in the PET signal in AD.
Substances chimiques
Carrier Proteins
0
Receptors, GABA
0
TSPO protein, human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1322-1343Informations de copyright
© 2022 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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