The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments.
fat
men
obesity
testosterone
Journal
Obesity reviews : an official journal of the International Association for the Study of Obesity
ISSN: 1467-789X
Titre abrégé: Obes Rev
Pays: England
ID NLM: 100897395
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
09
01
2022
received:
03
10
2021
accepted:
09
01
2022
pubmed:
28
1
2022
medline:
11
5
2022
entrez:
27
1
2022
Statut:
ppublish
Résumé
Obesity is associated with hypothalamic-pituitary-testicular axis dysregulation in males. Here, we summarize recent evidence derived from clinical trials and studies in preclinical animal models regarding the role of androgen receptor (AR) signaling in the pathophysiology of males with obesity. We also discuss therapeutic strategies targeting the AR for the treatment of obesity and their limitations and provide insight into the future research necessary to advance this field.
Identifiants
pubmed: 35083843
doi: 10.1111/obr.13429
pmc: PMC9286619
doi:
Substances chimiques
Receptors, Androgen
0
Testosterone
3XMK78S47O
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13429Informations de copyright
© 2022 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
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