Diagnosis delays in the UK according to pre or postmigration acquisition of HIV.
Journal
AIDS (London, England)
ISSN: 1473-5571
Titre abrégé: AIDS
Pays: England
ID NLM: 8710219
Informations de publication
Date de publication:
01 03 2022
01 03 2022
Historique:
entrez:
27
1
2022
pubmed:
28
1
2022
medline:
9
4
2022
Statut:
ppublish
Résumé
The aim of this study was to evaluate whether infection occurred pre or postmigration and the associated diagnosis delay in migrants diagnosed with HIV in the UK. We analyzed a cohort of individuals diagnosed with HIV in the UK in 2014-2016 born in Africa or elsewhere in Europe. Inclusion criteria were arrival within 15 years before diagnosis, availability of HIV pol sequence, and viral subtype shared by at least 10 individuals. We examined phylogenies for evidence of infection after entry into the UK and incorporated this information into a Bayesian analysis of timing of infection using biomarkers of CD4+ cell count, avidity assays, proportion of ambiguous nucleotides in viral sequences, and last negative test dates where available. One thousand, two hundred and fifty-six individuals were included. The final model indicated that HIV was acquired postmigration for most MSM born in Europe (posterior expectation 65%, 95% credibility interval 64-67%) or Africa (65%, 62-69%), whereas a minority (20-30%) of men and women with heterosexual transmission acquired HIV postmigration. Estimated diagnosis delays were lower for MSM than for those with heterosexual transmission, and were lower for those with postmigration infection across all subgroups. For MSM acquiring HIV postmigration, the estimated mean time to diagnosis was less than one year, but for those who acquired HIV premigration, the mean time from infection to diagnosis was more than five years for all subgroups. Acquisition of HIV postmigration is common, particularly among MSM, calling for prevention efforts aimed at migrant communities. Delays in diagnosis reinforce the need for targeted testing initiatives.
Identifiants
pubmed: 35084383
doi: 10.1097/QAD.0000000000003110
pii: 00002030-202203010-00011
pmc: PMC7612284
mid: EMS137093
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
415-422Subventions
Organisme : Medical Research Council
ID : MC_PC_19012
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M004236/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R015600/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : 164587
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Références
Nash S, Desai S, Croxford S, Guerra L, Lowndes C, Connor N, et al. Progress towards ending the HIV epidemic in the United Kingdom: 2018 report . London: Public Health England; 2018.
Brown A, Nash S, Connor N, Kirwan P, Ogaz D, Croxford S, et al. Towards elimination of HIV transmission, AIDS and HIV-related deaths in the UK . HIV Med 2018; 19:505–512.
Rodger AJ, Cambiano V, Bruun T, Vernazza P, Collins S, Degen O, et al. Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study . Lancet 2019; 393:2428–2438.
Shah A, Sun S, Brown A, Nash S, Harris R, Kirwan P, et al. Trends in HIV testing, new diagnoses and people receiving HIV-related care in the United Kingdom: data to the end of December 2019. Health Protection Report Volume 14 Number 20 . London: Public Health England; 2020.
Rice BD, Elford J, Yin Z, Delpech VC. A new method to assign country of HIV infection among heterosexuals born abroad and diagnosed with HIV . AIDS 2012; 26:1961–1966.
Giardina F, Romero-Severson EO, Axelsson M, Svedhem V, Leitner T, Britton T, et al. Getting more from heterogeneous HIV-1 surveillance data in a high immigration country: estimation of incidence and undiagnosed population size using multiple biomarkers . Int J Epidemiol 2019; 48:1795–1803.
Stirrup OT, Dunn DT. Estimation of delay to diagnosis and incidence in HIV using indirect evidence of infection dates . BMC Med Res Methodol 2018; 18:65.
Bezemer D, Cori A, Ratmann O, van Sighem A, Hermanides HS, Dutilh BE, et al. Dispersion of the HIV-1 epidemic in men who have sex with men in the Netherlands: a combined mathematical model and phylogenetic analysis . PLOS Med 2015; 12:e1001898.
Cane PCI, Dunn D, Evans B, Geretti AM, Green H, Phillips A, et al. UK Group on Transmitted HIV Drug Resistance. Time trends in primary resistance to HIV drugs in the United Kingdom: multicentre observational study . BMJ 2005; 331:1368.
Public Health England. Guidance: HIV surveillance systems. https://www.gov.uk/guidance/hiv-surveillance-systems [Accessed 26 July 2021].
Serhir B, Hamel D, Doualla-Bell F, Routy JP, Beaulac S-N, Legault M, et al. Performance of Bio-Rad and limiting antigen avidity assays in detecting recent HIV infections using the Quebec primary HIV-1 infection cohort . PLoS One 2016; 11:e0156023.
Kassanjee R, Pilcher CD, Keating SM, Facente SN, McKinney E, Price MA, et al. Independent assessment of candidate HIV incidence assays on specimens in the CEPHIA repository . AIDS 2014; 28:2439–2449.
Price MN, Dehal PS, Arkin AP. FastTree 2 – approximately maximum-likelihood trees for large alignments . PLoS One 2010; 5:e9490.
To T-H, Jung M, Lycett S, Gascuel O. Fast dating using least-squares criteria and algorithms . Syst Biol 2015; 65:82–97.
Wensing AM, Calvez V, Ceccherini-Silberstein F, Charpentier C, Günthard HF, Paredes R, et al. 2019 update of the drug resistance mutations in HIV-1 . Top Antivir Med 2019; 27:111–121.
Yu G, Smith DK, Zhu H, Guan Y, Lam TT-Y. ggtree: an r package for visualization and annotation of phylogenetic trees with their covariates and other associated data . Meth Ecol Evol 2017; 8:28–36.
Paradis E, Schliep K. ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R . Bioinformatics 2018; 35:526–528.
Ragonnet-Cronin M, Hodcroft E, Hué S, Fearnhill E, Delpech V, Brown AJL, et al. Automated analysis of phylogenetic clusters . BMC Bioinformatics 2013; 14:317.
UK Register of HIV Seroconverters Steering Committee. The AIDS incubation period in the UK estimated from a national register of HIV seroconverters . AIDS 1998; 12:659–667.
Carpenter B, Gelman A, Hoffman MD, Lee D, Goodrich B, Betancourt M, et al. Stan: a probabilistic programming language . J Stat Soft 2017; 76:32.
Alvarez-del Arco D, Fakoya I, Thomadakis C, Pantazis N, Touloumi G, Gennotte A-F, et al. High levels of postmigration HIV acquisition within nine European countries . AIDS 2017; 31:1979–1988.
Pantazis N, Thomadakis C, del Amo J, Alvarez-del Arco D, Burns FM, Fakoya I, et al. Determining the likely place of HIV acquisition for migrants in Europe combining subject-specific information and biomarkers data . Stat Methods Med Res 2019; 28:1979–1997.
Fakoya I, Álvarez-del Arco D, Woode-Owusu M, Monge S, Rivero-Montesdeoca Y, Delpech V, et al. A systematic review of postmigration acquisition of HIV among migrants from countries with generalised HIV epidemics living in Europe: implications for effectively managing HIV prevention programmes and policy . BMC Public Health 2015; 15:561.
Rice B, Elford J, Yin Z, Croxford S, Brown A, Delpech V. Trends in HIV diagnoses, HIV care, and uptake of antiretroviral therapy among heterosexual adults in England, Wales, and Northern Ireland . Sex Transm Dis 2014; 41:257–265.
Churchill D, Waters L, Ahmed N, Angus B, Boffito M, Bower M, et al. British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy . HIV Med 2016; 17:s2–s104.
Brown AE, Mohammed H, Ogaz D, Kirwan PD, Yung M, Nash SG, et al. Fall in new HIV diagnoses among men who have sex with men (MSM) at selected London sexual health clinics since early 2015: testing or treatment or preexposure prophylaxis (PrEP)? . Eurosurveillance 2017; 22:30553.
Bacchetti P, Moss AR. Incubation period of AIDS in San Francisco . Nature 1989; 338:251–253.
Fakoya I, Logan L, Ssanyu-Sseruma W, Howarth A, Murphy G, Johnson AM, et al. HIV testing and sexual health among Black African men and women in London, United Kingdom . JAMA Netw Open 2019; 2:e190864–e1190864.
Tostevin A, White E, Dunn D, Croxford S, Delpech V, Williams I, et al. Recent trends and patterns in HIV-1 transmitted drug resistance in the United Kingdom . HIV Med 2017; 18:204–213.