The Toll-like receptor 4 antagonist TAK-242 induces antidepressant-like effects in a rat learned helplessness model of depression through BDNF-TrkB signaling and AMPA receptor activation.
Animals
Antidepressive Agents
/ pharmacology
Behavior, Animal
/ drug effects
Brain-Derived Neurotrophic Factor
/ drug effects
Depression
/ drug therapy
Disease Models, Animal
Flavonoids
/ pharmacology
Helplessness, Learned
Male
Rats
Rats, Sprague-Dawley
Receptor, trkB
/ antagonists & inhibitors
Receptors, AMPA
/ antagonists & inhibitors
Signal Transduction
/ drug effects
Sulfonamides
/ pharmacology
Toll-Like Receptor 4
/ antagonists & inhibitors
Baicalin
Depression
Learned helplessness (LH)
Neuroinflammation
TAK-242
Toll-like receptor 4 (TLR4)
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
09 04 2022
09 04 2022
Historique:
received:
29
06
2021
revised:
28
12
2021
accepted:
21
01
2022
pubmed:
28
1
2022
medline:
22
3
2022
entrez:
27
1
2022
Statut:
ppublish
Résumé
Finding from animal models of depression indicated that Toll-like receptor 4 (TLR4) is associated with the pathophysiology of depression. Herein, the TLR4 antagonists TAK-242 and baicalin induced antidepressant-like effects in a rat learned helplessness model of depression. The antidepressant-like effects of both TLR4 antagonists were blocked by the TrkB inhibitor ANA-12. Also, the antidepressant-like effects of TAK-242 were blocked by the treatment with AMPA receptor antagonist NBQX. The antidepressant-like effects of the TLR4 antagonist TAK-242 involves BDNF-TrkB signaling and AMPA receptor activation.
Identifiants
pubmed: 35085701
pii: S0166-4328(22)00037-7
doi: 10.1016/j.bbr.2022.113769
pii:
doi:
Substances chimiques
Antidepressive Agents
0
Bdnf protein, rat
0
Brain-Derived Neurotrophic Factor
0
Flavonoids
0
Receptors, AMPA
0
Sulfonamides
0
Toll-Like Receptor 4
0
ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate
0
baicalin
347Q89U4M5
Ntrk2 protein, rat
EC 2.7.10.1
Receptor, trkB
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113769Informations de copyright
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