Mitral Annulus Calcification and Cardiac Conduction Disturbances: A DANCAVAS Sub-study.
Cardiac non-contrast computed tomography
Cardiac pacing, artificial
Electrocardiography
Heart block
Mitral annulus calcification
Journal
Journal of cardiovascular imaging
ISSN: 2586-7296
Titre abrégé: J Cardiovasc Imaging
Pays: Korea (South)
ID NLM: 101728106
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
24
06
2021
revised:
25
08
2021
accepted:
27
09
2021
entrez:
27
1
2022
pubmed:
28
1
2022
medline:
28
1
2022
Statut:
ppublish
Résumé
Due to its location very close to the bundle of His, mitral annulus calcification (MAC) might be associated with the development of atrioventricular (AV) conduction disturbances. This study assessed the association between MAC and AV conduction disturbances identified by cardiac implantable electronic device (CIED) use and electrocardiographic parameters. The association between MAC and traditional cardiovascular risk factors was also assessed. This cross-sectional study analyzed 14,771 participants, predominantly men aged 60-75 years, from the population-based Danish Cardiovascular Screening trial. Traditional cardiovascular risk factors were obtained. Using cardiac non-contrast computed tomography imaging, MAC scores were measured using the Agatston method and divided into absent versus present and score categories. CIED implantation data were obtained from the Danish Pacemaker and Implantable Cardioverter Defibrillator Register. A 12-lead electrocardiogram was available for 2,107 participants. Associations between MAC scores and AV conduction disturbances were assessed using multivariate regression analyses. MAC was present in 22.4% of the study subjects. Participants with pacemakers for an AV conduction disturbance had significantly higher MAC scores (odds ratio [OR], 1.11; 95% confidence interval [CI], 1.01-1.23) than participants without a CIED, whereas participants with a CIED for other reasons did not. Prolonged QRS-interval was significantly associated with the presence of MAC (OR, 1.45; 95% CI, 1.04-2.04), whereas prolonged PQ-interval was not. Female sex and most traditional cardiovascular risk factors were significantly associated with high MAC scores. MAC was associated with AV conduction disturbances, which could improve our understanding of the development of AV conduction disturbances.
Sections du résumé
BACKGROUND
BACKGROUND
Due to its location very close to the bundle of His, mitral annulus calcification (MAC) might be associated with the development of atrioventricular (AV) conduction disturbances. This study assessed the association between MAC and AV conduction disturbances identified by cardiac implantable electronic device (CIED) use and electrocardiographic parameters. The association between MAC and traditional cardiovascular risk factors was also assessed.
METHODS
METHODS
This cross-sectional study analyzed 14,771 participants, predominantly men aged 60-75 years, from the population-based Danish Cardiovascular Screening trial. Traditional cardiovascular risk factors were obtained. Using cardiac non-contrast computed tomography imaging, MAC scores were measured using the Agatston method and divided into absent versus present and score categories. CIED implantation data were obtained from the Danish Pacemaker and Implantable Cardioverter Defibrillator Register. A 12-lead electrocardiogram was available for 2,107 participants. Associations between MAC scores and AV conduction disturbances were assessed using multivariate regression analyses.
RESULTS
RESULTS
MAC was present in 22.4% of the study subjects. Participants with pacemakers for an AV conduction disturbance had significantly higher MAC scores (odds ratio [OR], 1.11; 95% confidence interval [CI], 1.01-1.23) than participants without a CIED, whereas participants with a CIED for other reasons did not. Prolonged QRS-interval was significantly associated with the presence of MAC (OR, 1.45; 95% CI, 1.04-2.04), whereas prolonged PQ-interval was not. Female sex and most traditional cardiovascular risk factors were significantly associated with high MAC scores.
CONCLUSIONS
CONCLUSIONS
MAC was associated with AV conduction disturbances, which could improve our understanding of the development of AV conduction disturbances.
Identifiants
pubmed: 35086172
pii: 30.62
doi: 10.4250/jcvi.2021.0110
pmc: PMC8792721
doi:
Types de publication
Journal Article
Langues
eng
Pagination
62-75Subventions
Organisme : Syddansk Universitet
Pays : Denmark
Organisme : Region of Southern Denmark
Pays : Denmark
Informations de copyright
Copyright © 2022 Korean Society of Echocardiography.
Déclaration de conflit d'intérêts
The authors have no financial conflicts of interest.
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