A new platform for ultra-high dose rate radiobiological research using the BELLA PW laser proton beamline.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 01 2022
27 01 2022
Historique:
received:
25
06
2021
accepted:
04
01
2022
entrez:
28
1
2022
pubmed:
29
1
2022
medline:
8
3
2022
Statut:
epublish
Résumé
Radiotherapy is the current standard of care for more than 50% of all cancer patients. Improvements in radiotherapy (RT) technology have increased tumor targeting and normal tissue sparing. Radiations at ultra-high dose rates required for FLASH-RT effects have sparked interest in potentially providing additional differential therapeutic benefits. We present a new experimental platform that is the first one to deliver petawatt laser-driven proton pulses of 2 MeV energy at 0.2 Hz repetition rate by means of a compact, tunable active plasma lens beamline to biological samples. Cell monolayers grown over a 10 mm diameter field were exposed to clinically relevant proton doses ranging from 7 to 35 Gy at ultra-high instantaneous dose rates of 10
Identifiants
pubmed: 35087083
doi: 10.1038/s41598-022-05181-3
pii: 10.1038/s41598-022-05181-3
pmc: PMC8795353
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1484Subventions
Organisme : Laboratory Directed Research and Development
ID : DE-AC02-05CH11231
Organisme : U.S. Department of Energy
ID : DE-AC02-05CH11231
Informations de copyright
© 2022. The Author(s).
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