The Role of Exercise-Induced Molecular Processes and Vitamin D in Improving Cardiorespiratory Fitness and Cardiac Rehabilitation in Patients With Heart Failure.
exercise
heart failure
hypertrophy
inflammation
vitamin D
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
10
2021
accepted:
13
12
2021
entrez:
28
1
2022
pubmed:
29
1
2022
medline:
29
1
2022
Statut:
epublish
Résumé
Heart failure (HF) still affects millions of people worldwide despite great advances in therapeutic approaches in the cardiovascular field. Remarkably, unlike pathological hypertrophy, exercise leads to beneficial cardiac hypertrophy characterized by normal or enhanced contractile function. Exercise-based cardiac rehabilitation improves cardiorespiratory fitness and, as a consequence, ameliorates the quality of life of patients with HF. Particularly, multiple studies demonstrated the improvement in left ventricular ejection fraction (LVEF) among patients with HF due to the various processes in the myocardium triggered by exercise. Exercise stimulates IGF-1/PI3K/Akt pathway activation involved in muscle growth in both the myocardium and skeletal muscle by regulating protein synthesis and catabolism. Also, physical activity stimulates the activation of the mitogen-activated protein kinase (MAPK) pathway which regulates cellular proliferation, differentiation and apoptosis. In addition, emerging data pointed out the anti-inflammatory effects of exercises as well. Therefore, it is of utmost importance for clinicians to accurately evaluate the patient's condition by performing a cardiopulmonary exercise test and/or a 6-min walking test. Portable devices with the possibility to measure exercise capacity proved to be very useful in this setting as well. The aim of this review is to gather together the molecular processes triggered by the exercise and available therapies in HF settings that could ameliorate heart performance, with a special focus on strategies such as exercise-based cardiac rehabilitation.
Identifiants
pubmed: 35087418
doi: 10.3389/fphys.2021.794641
pmc: PMC8787056
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
794641Informations de copyright
Copyright © 2022 Aleksova, Janjusevic, Gagno, Pierri, Padoan, Fluca, Carriere, Beltrami and Sinagra.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nat Rev Cardiol. 2016 Jun;13(6):368-78
pubmed: 26935038
Front Cardiovasc Med. 2018 Jul 12;5:87
pubmed: 30050908
Eur Heart J. 2021 Jan 1;42(1):17-96
pubmed: 32860412
Eur Heart J. 2017 Aug 1;38(29):2279-2286
pubmed: 28498942
Eur J Prev Cardiol. 2016 Jan;23(1):4-13
pubmed: 25488549
Eur Heart J. 2021 Dec 21;42(48):4901
pubmed: 34649282
PLoS One. 2012;7(4):e35552
pubmed: 22523601
Eur Respir J. 2017 Aug 3;50(2):
pubmed: 28775050
Cardiovasc Res. 2005 Aug 1;67(2):187-97
pubmed: 15935334
J Am Coll Cardiol. 1999 Oct;34(4):1170-5
pubmed: 10520808
Life Sci. 2020 Mar 1;244:117305
pubmed: 31953161
Int J Mol Sci. 2021 May 06;22(9):
pubmed: 34066533
J Appl Physiol (1985). 2009 Oct;107(4):1006-14
pubmed: 19696361
Arq Bras Cardiol. 2016 Jan;106(1):62-9
pubmed: 26647721
Acta Physiol (Oxf). 2017 Feb;219(2):382-408
pubmed: 27246807
Eur J Prev Cardiol. 2020 Dec;27(2_suppl):52-58
pubmed: 33238741
Respir Care. 2003 Aug;48(8):783-5
pubmed: 12890299
Crit Rev Food Sci Nutr. 2021 Jun 2;:1-21
pubmed: 34076544
Biochim Biophys Acta. 2011 May;1813(5):878-88
pubmed: 21296109
J Nucl Med. 2007 Nov;48(11):1800-15
pubmed: 17942804
Diabetes Obes Metab. 2008 Mar;10(3):185-97
pubmed: 18269634
Front Nutr. 2021 Sep 23;8:740855
pubmed: 34631770
J Endocr Soc. 2021 Jul 15;5(10):bvab124
pubmed: 34396023
J Am Heart Assoc. 2020 Feb 4;9(3):e013695
pubmed: 32009524
J Diabetes Res. 2014;2014:320930
pubmed: 25243195
Circulation. 2010 Sep 21;122(12):1221-38
pubmed: 20855669
Ann Am Thorac Soc. 2017 Jul;14(Supplement_1):S3-S11
pubmed: 28510504
Joint Bone Spine. 2010 Dec;77(6):552-7
pubmed: 21067953
Ann Intern Med. 2000 Jun 6;132(11):862-70
pubmed: 10836912
Skelet Muscle. 2011 Jan 24;1(1):4
pubmed: 21798082
Pharmacol Ther. 2010 Oct;128(1):191-227
pubmed: 20438756
Circulation. 2003 Mar 4;107(8):1210-25
pubmed: 12615804
Cochrane Database Syst Rev. 2016 Jan 05;(1):CD001800
pubmed: 26730878
Front Endocrinol (Lausanne). 2018 Jan 17;9:2
pubmed: 29387042
Am J Physiol Heart Circ Physiol. 2021 Apr 1;320(4):H1566-H1600
pubmed: 33385323
Am J Physiol Heart Circ Physiol. 2017 Jul 1;313(1):H72-H88
pubmed: 28476924
Circulation. 2017 Feb 28;135(9):839-849
pubmed: 28082387
Biomed Res Int. 2015;2015:145828
pubmed: 26000281
N Engl J Med. 2007 Jul 19;357(3):266-81
pubmed: 17634462
Exp Physiol. 2021 Jul;106(7):1460-1469
pubmed: 33823058
Eur J Heart Fail. 2014 Feb;16(2):180-8
pubmed: 24464981
Nat Metab. 2020 Sep;2(9):829-839
pubmed: 32807982
J Am Coll Cardiol. 1996 Dec;28(7):1652-60
pubmed: 8962548
Eur Heart J. 2013 Jun;34(24):1790-9
pubmed: 23569199
Eur J Prev Cardiol. 2014 Dec;21(12):1465-73
pubmed: 23864363
Circulation. 2013 Dec 3;128(23):2517-31
pubmed: 24297817
Am J Physiol Endocrinol Metab. 2014 Sep 15;307(6):E469-84
pubmed: 25096180
Lancet. 2015 Jul 18;386(9990):266-73
pubmed: 25982160
Nutrients. 2016 Mar 02;8(3):135
pubmed: 26950144
FEBS J. 2005 Jun;272(11):2684-95
pubmed: 15943803
Med Sci Sports Exerc. 2009 May;41(5):1102-10
pubmed: 19346976
Physiol Rev. 2018 Jan 1;98(1):419-475
pubmed: 29351515
J Cardiovasc Dev Dis. 2021 Jul 25;8(8):
pubmed: 34436227
Eur J Heart Fail. 2008 Nov;10(11):1127-35
pubmed: 18835539
Curr Heart Fail Rep. 2011 Jun;8(2):123-30
pubmed: 21328082
Int J Mol Sci. 2019 Aug 05;20(15):
pubmed: 31387330
Am J Med Sci. 2009 Jul;338(1):40-4
pubmed: 19593102
Curr Opin Clin Nutr Metab Care. 2009 Nov;12(6):628-33
pubmed: 19770647
World J Cardiol. 2020 Aug 26;12(8):373-408
pubmed: 32879702
Circulation. 1992 Jun;85(6):2119-31
pubmed: 1591831
JAMA Cardiol. 2017 Jun 1;2(6):608-616
pubmed: 28384800
Oncogene. 2016 Oct 13;35(41):5362-5376
pubmed: 27041576
Int J Cardiol. 2016 Nov 15;223:596-603
pubmed: 27561166
Eur J Heart Fail. 2018 Jan;20(1):3-15
pubmed: 28925073
Mol Cell Endocrinol. 2011 Dec 5;347(1-2):11-6
pubmed: 21664245
Front Cardiovasc Med. 2018 Sep 11;5:127
pubmed: 30255026
Cell Metab. 2017 May 2;25(5):1012-1026
pubmed: 28467921
J Am Acad Orthop Surg. 2018 Apr 15;26(8):278-285
pubmed: 29561306
Cell. 2017 Apr 6;169(2):361-371
pubmed: 28388417
Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):435-44
pubmed: 14604834
ESC Heart Fail. 2018 Apr;5(2):222-232
pubmed: 29235244
Eur J Prev Cardiol. 2019 Dec;26(18):1921-1928
pubmed: 31219704
PLoS One. 2018 Apr 19;13(4):e0193070
pubmed: 29672520
Front Biosci. 2008 Jan 01;13:336-46
pubmed: 17981551
Front Cardiovasc Med. 2018 Sep 28;5:135
pubmed: 30324108
Int J Vitam Nutr Res. 2015;85(1-2):23-30
pubmed: 26780274
Clin Exp Pharmacol Physiol. 2007 Apr;34(4):255-62
pubmed: 17324134
J Adv Res. 2016 Sep;7(5):671-9
pubmed: 27504197
Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 1):1384-7
pubmed: 9817683
Eur Respir Rev. 2021 Jan 6;30(159):
pubmed: 33408087
JMIR Mhealth Uhealth. 2020 Jan 3;8(1):e13756
pubmed: 31899457
Can J Physiol Pharmacol. 2009 Jul;87(7):493-514
pubmed: 19767873
Heart. 2015 May 15;101(10):758-65
pubmed: 25911667
Neuroimmunomodulation. 2015;22(1-2):20-32
pubmed: 25227506
J Sports Sci Med. 2009 Mar 01;8(1):67-76
pubmed: 24150558
JAMA Cardiol. 2019 Aug 1;4(8):765-776
pubmed: 31215980
JACC Heart Fail. 2013 Feb;1(1):84-90
pubmed: 24614995
Physiol Rev. 2016 Jan;96(1):99-125
pubmed: 26607287
J Clin Med. 2020 Jul 06;9(7):
pubmed: 32640692
JAMA. 2021 Feb 9;325(6):542-551
pubmed: 33560320
Eur Heart J. 2003 Jul;24(14):1304-13
pubmed: 12871687
N Engl J Med. 2019 Jan 3;380(1):33-44
pubmed: 30415629
J Clin Endocrinol Metab. 2017 Nov 1;102(11):3937-3944
pubmed: 28973380
Nat Rev Immunol. 2011 Aug 05;11(9):607-15
pubmed: 21818123
J Nephropathol. 2014;3(2):41-3
pubmed: 24772394
Scand J Prim Health Care. 2010 Sep;28(3):166-71
pubmed: 20642395
Cardiovasc Res. 2006 Nov 1;72(2):231-40
pubmed: 16945356