The association of vascular endothelial growth factor related SNPs and circulating iron levels might depend on body mass index.

Body Mass Index Genotype Humans Iron Polymorphism, Single Nucleotide Vascular Endothelial Growth Factor A / genetics Vascular Endothelial Growth Factors
Body mass index Iron levels SNPs Vascular endothelial growth factor

Journal

Frontiers in bioscience (Landmark edition)
ISSN: 2768-6698
Titre abrégé: Front Biosci (Landmark Ed)
Pays: Singapore
ID NLM: 101612996

Informations de publication

Date de publication:
18 01 2022
Historique:
received: 26 05 2021
revised: 09 08 2021
accepted: 24 08 2021
entrez: 29 1 2022
pubmed: 30 1 2022
medline: 2 4 2022
Statut: ppublish

Résumé

Vascular Endothelial Growth Factor (VEGF) is an essential regulator of vascular biology. In addition to the well-established role in angiogenesis, circulating VEGF levels were found elevated in severely anemic patients, pointing out that anemia might affect the progression of angiogenesis in malignant and benign diseases through the alteration of VEGF levels. Ten single nucleotide polymorphisms (SNPs) in We found that the rs10738760 and the body mass index (BMI) were associated with decreased Iron levels (

Sections du résumé

BACKGROUND AND OBJECTIVES
Vascular Endothelial Growth Factor (VEGF) is an essential regulator of vascular biology. In addition to the well-established role in angiogenesis, circulating VEGF levels were found elevated in severely anemic patients, pointing out that anemia might affect the progression of angiogenesis in malignant and benign diseases through the alteration of VEGF levels. Ten single nucleotide polymorphisms (SNPs) in
RESULT
We found that the rs10738760 and the body mass index (BMI) were associated with decreased Iron levels (

Identifiants

DOI: 10.31083/j.fbl2701027 PMID: 35090332
pubmed: 35090332
pii: S2768-6701(22)00365-3
doi: 10.31083/j.fbl2701027
doi:

Substances chimiques

VEGFA protein, human 0
Vascular Endothelial Growth Factor A 0
Vascular Endothelial Growth Factors 0
Iron E1UOL152H7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

27

Informations de copyright

© 2022 The Author(s). Published by IMR Press.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Auteurs

Pia Chedid (P)

Université de Lorraine, IGE-PCV, F-54000 Nancy, France.
Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Balamand, 1100-2807 Beirut, Lebanon.

Ali Salami (A)

Université de Lorraine, IGE-PCV, F-54000 Nancy, France.
Department of Mathematics, Faculty of Sciences, Lebanese University, 1700 Nabatieh, Lebanon.

Mariam Ibrahim (M)

Rammal Hassan Rammal Research Laboratory, PhyToxE Research Group, Faculty of Sciences (V), Lebanese University, 1700 Nabatieh, Lebanon.

Sophie Visvikis-Siest (S)

Université de Lorraine, IGE-PCV, F-54000 Nancy, France.

Said El Shamieh (S)

Department of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, 115020 Beirut, Lebanon.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › The association of vascular endothelial growth...
questionsmedicales.fr › Phénomènes génétiques › Génotype › The association of vascular endothelial growth...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The association of vascular endothelial growth...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › The association of vascular endothelial growth...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › The association of vascular endothelial growth...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines angiogéniques › Facteurs de croissance endothéliale vasculaire › Facteur de croissance endothéliale vasculaire de type A › The association of vascular endothelial growth...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines angiogéniques › Facteurs de croissance endothéliale vasculaire › The association of vascular endothelial growth...