A new direction in managing avulsed teeth: stem cell-based de novo PDL regeneration.
Animal models
Avulsion
Cell sheet
Cell-based PDL regeneration
Dog
Mini-swine
Periodontal ligament (PDL)
Periodontal ligament stem cells (PDLSCs)
Tooth replantation
Traumatic injury
Journal
Stem cell research & therapy
ISSN: 1757-6512
Titre abrégé: Stem Cell Res Ther
Pays: England
ID NLM: 101527581
Informations de publication
Date de publication:
28 01 2022
28 01 2022
Historique:
received:
01
06
2021
accepted:
16
11
2021
entrez:
29
1
2022
pubmed:
30
1
2022
medline:
24
3
2022
Statut:
epublish
Résumé
Management of avulsed teeth after replantation often leads to an unfavorable outcome. Damage to the thin and vulnerable periodontal ligament is the key reason for failure. Cell- or stem cell-based regenerative medicine has emerged in the past two decades as a promising clinical treatment modality to improve treatment outcomes. This concept has also been tested for the management of avulsed teeth in animal models. This review focuses on the discussion of limitation of current management protocols for avulsed teeth, cell-based therapy for periodontal ligament (PDL) regeneration in small and large animals, the challenges of de novo regeneration of PDL on denuded root in the edentulous region using a mini-swine model, and establishing a prospective new clinical protocol to manage avulsed teeth based on the current progress of cell-based PDL regeneration studies.
Identifiants
pubmed: 35090556
doi: 10.1186/s13287-022-02700-x
pii: 10.1186/s13287-022-02700-x
pmc: PMC8796335
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
34Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE019156
Pays : United States
Informations de copyright
© 2022. The Author(s).
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