Fertility counseling in women with hereditary cancer syndromes.
Fertility preservation
Hereditary cancer syndrome
Oocytes cryopreservation
Oocytes donation
Preimplantation genetic diagnosis
Journal
Critical reviews in oncology/hematology
ISSN: 1879-0461
Titre abrégé: Crit Rev Oncol Hematol
Pays: Netherlands
ID NLM: 8916049
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
30
10
2021
revised:
16
01
2022
accepted:
21
01
2022
pubmed:
30
1
2022
medline:
3
3
2022
entrez:
29
1
2022
Statut:
ppublish
Résumé
Hereditary cancer syndromes are a heterogeneous group of genetic conditions that are associated with an increased risk of developing cancer during lifespan. In affected women, parenthood may be accompanied by concerns for the offspring, considering the common autosomal dominant inheritance. Moreover, fertility preservation to prevent the detrimental effects of cancer treatments differs compared to other clinical contexts. The necessity to preserve gametes is indeed predictable and expected to be common. For these reasons, we advocate a personalized and early fertility counseling. Carriers should be aware of the risk of transmission. The possibility to perform elective oocytes cryopreservation, either before (previvors) or after (survivors) cancer diagnosis should be discussed. Finally, they should be informed about the options of preimplantation genetic test (PGT) and oocytes donation. In conclusion, physicians engaged in oncofertility should personalize the counseling for women with hereditary cancer syndromes, being aware of their peculiar needs.
Identifiants
pubmed: 35091060
pii: S1040-8428(22)00028-2
doi: 10.1016/j.critrevonc.2022.103604
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103604Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.