Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury.
Journal
NPJ Regenerative medicine
ISSN: 2057-3995
Titre abrégé: NPJ Regen Med
Pays: United States
ID NLM: 101699846
Informations de publication
Date de publication:
28 Jan 2022
28 Jan 2022
Historique:
received:
12
05
2021
accepted:
20
12
2021
entrez:
29
1
2022
pubmed:
30
1
2022
medline:
30
1
2022
Statut:
epublish
Résumé
Since Schwann cells (SCs) support axonal growth at development as well as after peripheral nerve injury (PNI), developing SCs might be able to promote axon regeneration after PNI. The purpose of the current study was to elucidate the capability of developing SCs to induce axon regeneration after PNI. SC precursors (SCPs), immature SCs (ISCs), repair SCs (RSCs) from injured nerves, and non-RSCs from intact nerves were tested by grafting into acellular region of rat sciatic nerve with crush injury. Both of developing SCs completely failed to support axon regeneration, whereas both of mature SCs, especially RSCs, induced axon regeneration. Further, RSCs but not SCPs promoted neurite outgrowth of adult dorsal root ganglion neurons. Transcriptome analysis revealed that the gene expression profiles were distinctly different between RSCs and SCPs. These findings indicate that developing SCs are markedly different from mature SCs in terms of functional and molecular aspects and that RSC is a viable candidate for regenerative cell therapy for PNI.
Identifiants
pubmed: 35091563
doi: 10.1038/s41536-022-00205-y
pii: 10.1038/s41536-022-00205-y
pmc: PMC8799715
doi:
Types de publication
Journal Article
Langues
eng
Pagination
12Subventions
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP20gm6210004
Informations de copyright
© 2022. The Author(s).
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