Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats.
Anti-PEG antibody
Choroid plexus
Polyethylene glycol
Vacuolation
Journal
Toxicology letters
ISSN: 1879-3169
Titre abrégé: Toxicol Lett
Pays: Netherlands
ID NLM: 7709027
Informations de publication
Date de publication:
15 Apr 2022
15 Apr 2022
Historique:
received:
22
10
2021
revised:
04
01
2022
accepted:
24
01
2022
pubmed:
30
1
2022
medline:
15
3
2022
entrez:
29
1
2022
Statut:
ppublish
Résumé
Polyethylene glycol (PEG) is present in a variety of products. Little is known regarding the accumulation of high-molecular-weight PEGs or the long-term effects resulting from PEG accumulation in certain tissues, especially the choroid plexus. We evaluated the toxicity of high-molecular-weight PEGs administered to Sprague Dawley rats. Groups of 12 rats per sex were administered subcutaneous injections of 20, 40, or 60 kDa PEG or intravenous injections of 60 kDa PEG at 100 mg PEG/kg body weight/injection once a week for 24 weeks. A significant decrease in triglycerides occurred in the 60 kDa PEG groups. PEG treatment led to a molecular-weight-related increase in PEG in plasma and a low level of PEG in cerebrospinal fluid. PEG was excreted in urine and feces, with a molecular-weight-related decrease in the urinary excretion. A higher prevalence of anti-PEG IgM was observed in PEG groups; anti-PEG IgG was not detected. PEG treatment produced a molecular-weight-related increase in vacuolation in the spleen, lymph nodes, lungs, and ovaries/testes, without an inflammatory response. Mast cell infiltration at the application site was noted in all PEG-treated groups. These data indicate that subcutaneous and intravenous exposure to high-molecular-weight PEGs produces anti-PEG IgM antibody responses and tissue vacuolation without inflammation.
Identifiants
pubmed: 35092809
pii: S0378-4274(22)00023-6
doi: 10.1016/j.toxlet.2022.01.011
pmc: PMC8932377
mid: NIHMS1779302
pii:
doi:
Substances chimiques
Antibodies
0
Polyethylene Glycols
3WJQ0SDW1A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
22-30Subventions
Organisme : Intramural FDA HHS
ID : FD999999
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
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