Investigating Toxin Diversity and Abundance in Snake Venom Proteomes.
mass spectrometry
protein family classification
proteomics
snake
toxin
transcriptomics
venom
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
31
08
2021
accepted:
10
12
2021
entrez:
31
1
2022
pubmed:
1
2
2022
medline:
1
2
2022
Statut:
epublish
Résumé
Understanding snake venom proteomes is becoming increasingly important to understand snake venom biology, evolution and especially clinical effects of venoms and approaches to antivenom development. To explore the current state of snake venom proteomics and transcriptomics we investigated venom proteomic methods, associations between methodological and biological variability and the diversity and abundance of protein families. We reviewed available studies on snake venom proteomes from September 2017 to April 2021. This included 81 studies characterising venom proteomes of 79 snake species, providing data on relative toxin abundance for 70 species and toxin diversity (number of different toxins) for 37 species. Methodologies utilised in these studies were summarised and compared. Several comparative studies showed that preliminary decomplexation of crude venom by chromatography leads to increased protein identification, as does the use of transcriptomics. Combining different methodological strategies in venomic approaches appears to maximize proteome coverage. 48% of studies used the RP-HPLC →1D SDS-PAGE →
Identifiants
pubmed: 35095489
doi: 10.3389/fphar.2021.768015
pii: 768015
pmc: PMC8795951
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
768015Informations de copyright
Copyright © 2022 Tasoulis, Pukala and Isbister.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Proteomics. 2018 Feb 10;172:173-189
pubmed: 28843532
Toxicon. 2019 Apr 15;162:40-45
pubmed: 30853409
Int J Biol Macromol. 2020 Apr 24;:
pubmed: 32339578
J Venom Anim Toxins Incl Trop Dis. 2017 Oct 18;23:44
pubmed: 29075288
J Proteome Res. 2020 Aug 7;19(8):3518-3532
pubmed: 32686412
Proc Biol Sci. 2020 May 13;287(1926):20200613
pubmed: 32345154
Proc Biol Sci. 2019 Jul 10;286(1906):20190810
pubmed: 31266424
Toxicon. 2008 Aug 1;52(2):264-76
pubmed: 18619481
J Proteomics. 2020 Mar 30;216:103680
pubmed: 32028038
Rapid Commun Mass Spectrom. 2019 May;33 Suppl 1:20-27
pubmed: 30076652
Biochim Biophys Acta Gen Subj. 2017 Apr;1861(4):814-823
pubmed: 28130154
J Proteomics. 2017 Aug 8;165:138-140
pubmed: 28743377
J Proteomics. 2018 Sep 15;187:223-234
pubmed: 30092380
Toxins (Basel). 2018 Mar 23;10(4):
pubmed: 29570631
J Proteomics. 2017 Mar 22;157:18-32
pubmed: 28159706
Expert Rev Proteomics. 2015;12(5):557-73
pubmed: 26400467
Toxins (Basel). 2016 Oct 18;8(10):
pubmed: 27763543
Biomolecules. 2020 Sep 05;10(9):
pubmed: 32899462
Expert Rev Proteomics. 2018 Jul;15(7):555-568
pubmed: 30005583
J Proteome Res. 2013 Jul 5;12(7):3460-70
pubmed: 23731212
Toxicon. 2019 Aug;166:39-45
pubmed: 31091423
Evolution. 2015 Mar;69(3):823-9
pubmed: 25641367
Vaccine. 2010 Jan 8;28(3):798-802
pubmed: 19879227
Toxins (Basel). 2018 Oct 26;10(11):
pubmed: 30373186
J Proteomics. 2019 May 15;199:31-50
pubmed: 30763806
Expert Rev Proteomics. 2020 Oct;17(10):719-733
pubmed: 33232185
J Proteome Res. 2020 Apr 3;19(4):1731-1749
pubmed: 32073270
Molecules. 2018 Jul 29;23(8):
pubmed: 30060607
Toxicon. 2016 Nov;122:7-25
pubmed: 27641749
Gene. 2012 Mar 15;496(1):1-7
pubmed: 22285376
Proteomics. 2004 Feb;4(2):327-38
pubmed: 14760702
Expert Rev Proteomics. 2014 Jun;11(3):315-29
pubmed: 24678852
Toxicon. 2020 Oct 15;185:72-75
pubmed: 32615184
Genome Biol Evol. 2014 Aug;6(8):2088-95
pubmed: 25079342
Int J Biol Macromol. 2020 Oct 1;160:224-232
pubmed: 32439440
Mol Cell Proteomics. 2016 Jul;15(7):2423-34
pubmed: 27178327
Toxicon. 2012 Sep 15;60(4):449-54
pubmed: 22406471
Expert Rev Proteomics. 2011 Dec;8(6):739-58
pubmed: 22087658
Mol Cell Proteomics. 2005 Oct;4(10):1419-40
pubmed: 16009968
Toxicon. 2009 Sep 1;54(3):354-60
pubmed: 19393681
J Proteome Res. 2021 Jan 1;20(1):895-908
pubmed: 33225711
Toxicon. 2017 Sep 1;135:33-42
pubmed: 28602829
Toxins (Basel). 2021 Jun 17;13(6):
pubmed: 34204565
Toxicon. 2021 Jul 15;197:55-64
pubmed: 33894245
Toxins (Basel). 2017 Sep 18;9(9):
pubmed: 28927001
Trends Pharmacol Sci. 2020 Aug;41(8):570-581
pubmed: 32564899
J Proteome Res. 2011 Mar 4;10(3):1266-80
pubmed: 21171584
Toxicon X. 2021 Jun 12;9-10:100070
pubmed: 34195606
Nat Methods. 2013 Mar;10(3):186-7
pubmed: 23443629
Proc Natl Acad Sci U S A. 2020 May 19;117(20):10911-10920
pubmed: 32366667
Comp Biochem Physiol C Toxicol Pharmacol. 2020 Jan;227:108625
pubmed: 31634575
Mol Biol Evol. 2019 Sep 1;36(9):1964-1974
pubmed: 31220860
Proteomics. 2013 Sep;13(17):2567-78
pubmed: 23794183
Anal Chem. 2016 Oct 4;88(19):9699-9706
pubmed: 27593495
Toxins (Basel). 2021 Jan 19;13(1):
pubmed: 33477742
Toxicon. 2015 Dec 1;107(Pt B):163-74
pubmed: 26385313