Aflatoxin and the Etiology of Liver Cancer and Its Implications for Guatemala.
Aflatoxin
Guatemala
liver cancer
metabolic syndrome
obesity
Journal
World mycotoxin journal
ISSN: 1875-0710
Titre abrégé: World Mycotoxin J
Pays: Netherlands
ID NLM: 101486765
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
31
1
2022
pubmed:
1
2
2022
medline:
1
2
2022
Statut:
ppublish
Résumé
During the 60 years since the first scientific reports about a relation between aflatoxin exposure and adverse health consequences, both in animals and humans, there has been a remarkable number of basic, clinical and population science studies characterizing the impact of this mycotoxin on diseases such as liver cancer. Many of these human investigations to date have focused on populations residing in Asia and Africa due to the high incidence of liver cancer and high exposures to aflatoxin. These studies formed the basis for the International Agency for Research on Cancer to classify the aflatoxins as Group 1 known human carcinogens. In addition, aflatoxin contamination levels have been used in international commodity trade to set the price of various staples such as maize and groundnuts. While there have been many case-control and prospective cohort studies of liver cancer risk over the years there have been remarkably few investigations focused on liver cancer in Latin America. Our interdisciplinary and multiple institutional collaborative has been developing a long-term strategy to characterize the role of aflatoxin and other mycotoxins as health risk factors in Guatemala and neighboring countries. This paper summarizes a number of the investigations to date and provides a roadmap of our strategies for the near term to discern the emergent etiology of liver cancer in this region. With these data in hand public health-based prevention strategies could be strategically implemented and conducted to lower the impact of these mycotoxins on human health.
Identifiants
pubmed: 35096197
doi: 10.3920/wmj2020.2641
pmc: PMC8797158
mid: NIHMS1770031
doi:
Types de publication
Journal Article
Langues
eng
Pagination
305-317Subventions
Organisme : NCI NIH HHS
ID : P30 CA006973
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES007141
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA CP010158
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest: The authors have no conflicts of interest to disclose.
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