Solventless Microextration Techniques for Pharmaceutical Analysis: The Greener Solution.

SPME green analysis microextraction pharmaceuticals solventless extraction

Journal

Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988

Informations de publication

Date de publication:
2021
Historique:
received: 29 09 2021
accepted: 13 12 2021
entrez: 31 1 2022
pubmed: 1 2 2022
medline: 1 2 2022
Statut: epublish

Résumé

Extensive efforts have been made in the last decades to simplify the holistic sample preparation process. The idea of maximizing the extraction efficiency along with the reduction of extraction time, minimization/elimination of hazardous solvents, and miniaturization of the extraction device, eliminating sample pre- and posttreatment steps and reducing the sample volume requirement is always the goal for an analyst as it ensures the method's congruency with the green analytical chemistry (GAC) principles and steps toward sustainability. In this context, the microextraction techniques such as solid-phase microextraction (SPME), stir bar sorptive extraction (SBSE), microextraction by packed sorbent (MEPS), fabric phase sorptive extraction (FPSE), in-tube extraction dynamic headspace (ITEX-DHS), and PAL SPME Arrow are being very active areas of research. To help transition into wider applications, the new solventless microextraction techniques have to be commercialized, automated, and validated, and their operating principles to be anchored to theory. In this work, the benefits and drawbacks of the advanced microextraction techniques will be discussed and compared, together with their applicability to the analysis of pharmaceuticals in different matrices.

Identifiants

pubmed: 35096766
doi: 10.3389/fchem.2021.785830
pii: 785830
pmc: PMC8792605
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

785830

Informations de copyright

Copyright © 2022 Mohamed.

Déclaration de conflit d'intérêts

The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Heba M Mohamed (HM)

Higher Colleges of Technology-Dubai Women's Campus-Health Sciences, Dhabi, United Arab Emirates.

Classifications MeSH