Autoimmune Regulator (AIRE) Deficiency Does Not Affect Atherosclerosis and CD4 T Cell Immune Tolerance to Apolipoprotein B.

T cells adaptive immunity antigen-specific atherosclerosis autoimmune regulator dextramer immune tolerance thymic selection

Journal

Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388

Informations de publication

Date de publication:
2021
Historique:
received: 10 11 2021
accepted: 21 12 2021
entrez: 31 1 2022
pubmed: 1 2 2022
medline: 1 2 2022
Statut: epublish

Résumé

Atherosclerosis is a chronic, lipid-driven disease of medium sized arteries which causes myocardial infarction and stroke. Recently, an adaptive immune response against the plaque-associated autoantigen Apolipoprotein B100 (ApoB), the structural protein component of low-density lipoprotein, has been implicated in atherogenesis. In healthy individuals, CD4

Identifiants

pubmed: 35097028
doi: 10.3389/fcvm.2021.812769
pmc: PMC8792778
doi:

Types de publication

Journal Article

Langues

eng

Pagination

812769

Informations de copyright

Copyright © 2022 Nettersheim, Braumann, Kobiyama, Orecchioni, Vassallo, Miller, Ali, Roy, Saigusa, Wolf, Ley and Winkels.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Felix Sebastian Nettersheim (FS)

Department of Cardiology, University Hospital Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
La Jolla Institute for Immunology, La Jolla, CA, United States.

Simon Braumann (S)

Department of Cardiology, University Hospital Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

Kouji Kobiyama (K)

La Jolla Institute for Immunology, La Jolla, CA, United States.

Marco Orecchioni (M)

La Jolla Institute for Immunology, La Jolla, CA, United States.

Melanie Vassallo (M)

La Jolla Institute for Immunology, La Jolla, CA, United States.

Jacqueline Miller (J)

La Jolla Institute for Immunology, La Jolla, CA, United States.

Amal Ali (A)

La Jolla Institute for Immunology, La Jolla, CA, United States.

Payel Roy (P)

La Jolla Institute for Immunology, La Jolla, CA, United States.

Ryosuke Saigusa (R)

La Jolla Institute for Immunology, La Jolla, CA, United States.

Dennis Wolf (D)

Department of Cardiology and Angiology I, University Hospital Freiburg, Freiburg, Germany.

Klaus Ley (K)

La Jolla Institute for Immunology, La Jolla, CA, United States.
Department of Bioengineering, University of California, San Diego, San Diego, CA, United States.

Holger Winkels (H)

Department of Cardiology, University Hospital Cologne, Cologne, Germany.
La Jolla Institute for Immunology, La Jolla, CA, United States.

Classifications MeSH