Exotoxin-Targeted Drug Modalities as Antibiotic Alternatives.
antibiotic resistance
antibiotics
antivirulence therapy
bacteria
exotoxin
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
11 03 2022
11 03 2022
Historique:
pubmed:
1
2
2022
medline:
26
3
2022
entrez:
31
1
2022
Statut:
ppublish
Résumé
The paradigm of antivirulence therapy dictates that bacterial pathogens are specifically disarmed but not killed by neutralizing their virulence factors. Clearance of the invading pathogen by the immune system is promoted. As compared to antibiotics, the pathogen-selective antivirulence drugs hold promise to minimize collateral damage to the beneficial microbiome. Also, selective pressure for resistance is expected to be lower because bacterial viability is not directly affected. Antivirulence drugs are being developed for stand-alone prophylactic and therapeutic treatments but also for combinatorial use with antibiotics. This Review focuses on drug modalities that target bacterial exotoxins after the secretion or release-upon-lysis. Exotoxins have a significant and sometimes the primary role as the disease-causing virulence factor, and thereby they are attractive targets for drug development. We describe the key pre-clinical and clinical trial data that have led to the approval of currently used exotoxin-targeted drugs, namely the monoclonal antibodies bezlotoxumab (toxin B/TcdB,
Identifiants
pubmed: 35099182
doi: 10.1021/acsinfecdis.1c00296
pmc: PMC8922280
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Toxins
0
Exotoxins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
433-456Références
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