Dynole 34-2 and Acrylo-Dyn 2-30, Novel Dynamin GTPase Chemical Biology Probes.
Acrylo-Dyn
Chemical synthesis
Dynamin inhibitors
Dynole
Dynole 34-2
Dynole-31-2
Endocytosis
Molecular probes
Journal
Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
31
1
2022
pubmed:
1
2
2022
medline:
1
4
2022
Statut:
ppublish
Résumé
This protocol describes the chemical synthesis of the dynamin inhibitors Dynole 34-2 and Acrylo-Dyn 2-30, and their chemical scaffold matched partner inactive compounds. The chosen active and inactive paired compounds represent potent dynamin inhibitors and very closely related dynamin-inactive compounds, with the synthesis of three of the four compounds readily possible via a common intermediate. Combined with the assay data provided, this allows the interrogation of dynamin in vitro and potentially in vivo.
Identifiants
pubmed: 35099803
doi: 10.1007/978-1-0716-1916-2_17
doi:
Substances chimiques
Cyanoacrylates
0
Indoles
0
dynole 34-2
0
Dynamins
EC 3.6.5.5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
221-238Informations de copyright
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
Références
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