Transforming the Chemical Structure and Bio-Nano Activity of Doxorubicin by Ultrasound for Selective Killing of Cancer Cells.
cancer therapy
mitochondria
nanodrugs
ultrasound
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
revised:
24
01
2022
received:
05
10
2021
pubmed:
1
2
2022
medline:
5
4
2022
entrez:
31
1
2022
Statut:
ppublish
Résumé
Reconfiguring the structure and selectivity of existing chemotherapeutics represents an opportunity for developing novel tumor-selective drugs. Here, as a proof-of-concept, the use of high-frequency sound waves is demonstrated to transform the nonselective anthracycline doxorubicin into a tumor selective drug molecule. The transformed drug self-aggregates in water to form ≈200 nm nanodrugs without requiring organic solvents, chemical agents, or surfactants. The nanodrugs preferentially interact with lipid rafts in the mitochondria of cancer cells. The mitochondrial localization of the nanodrugs plays a key role in inducing reactive oxygen species mediated selective death of breast cancer, colorectal carcinoma, ovarian carcinoma, and drug-resistant cell lines. Only marginal cytotoxicity (80-100% cell viability) toward fibroblasts and cardiomyocytes is observed, even after administration of high doses of the nanodrug (25-40 µg mL
Identifiants
pubmed: 35100658
doi: 10.1002/adma.202107964
doi:
Substances chimiques
Antibiotics, Antineoplastic
0
Doxorubicin
80168379AG
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2107964Subventions
Organisme : Australian Research Council
ID : FT140100873
Organisme : National Health and Medical Research Council Senior Principal Research Fellowship
ID : GNT1135806
Organisme : European Union's Horizon 2020
Organisme : Marie Skłodowska-Curie
ID : 690901
Organisme : European Social Fund and European Regional Development Fund-Project MAGNET
ID : CZ.02.1.01/0.0/0.0/15_003/0000492
Organisme : European Union's horizon
Organisme : Marie Skłodowska-Curie
ID : 800924
Informations de copyright
© 2022 The Authors. Advanced Materials published by Wiley-VCH GmbH.
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