Hospital Frailty Risk Score predicts adverse events in older patients with vertebral compression fractures: Analysis of data in a nationwide in-patient database in Japan.
Hospital Frailty Risk Score
frailty
older people
vertebral compression fractures
Journal
Geriatrics & gerontology international
ISSN: 1447-0594
Titre abrégé: Geriatr Gerontol Int
Pays: Japan
ID NLM: 101135738
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
13
12
2021
received:
13
09
2021
accepted:
18
01
2022
pubmed:
1
2
2022
medline:
4
3
2022
entrez:
31
1
2022
Statut:
ppublish
Résumé
This study investigated the usefulness of frailty for predicting adverse events in patients with vertebral compression fractures (VCFs) during hospitalization using data obtained from the Japanese health insurance system. This retrospective cohort study of patients with VCFs aged ≥65 years was conducted using a nationwide database in Japan. We examined the relationships between frailty risk, classified using the Hospital Frailty Risk Score (HFRS), in-hospital mortality, and complications such as pressure ulcers and pneumonia. Multivariate logistic regression analysis was used to estimate the association between the HFRS and the outcomes of patients with VCFs. In this study, the data of 30 980 in-patients with VCFs were analyzed. Of these patients, 76.8%, 21.3%, and 1.9% had low, intermediate, and high risks of frailty, respectively. The higher the risk of frailty, the higher the rate of in-hospital mortality and the occurrence of all complications (P < 0.001 for trend). An intermediate risk of frailty was independently associated with in-hospital mortality (odds ratio [OR], 1.421; P < 0.001), whereas a high risk of frailty did not show statistical significance (OR, 1.385; P = 0.150). Each frailty risk was independently associated with the occurrence of all complications during hospitalization. The HFRS, which can assess the risk of frailty based on routinely collected medical records, was predictive of adverse events in older patients with VCFs based on a nationwide database in Japan. Future studies need to assess approaches to preventing adverse events in frail VCF patients. Geriatr Gerontol Int 2022; 22: 233-239.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
233-239Subventions
Organisme : National Mutual Insurance Federation of Agricultural Cooperatives
Informations de copyright
© 2022 Japan Geriatrics Society.
Références
Goldstein CL, Chutkan NB, Choma TJ, Orr RD. Management of the elderly with vertebral compression fractures. Neurosurgery 2015; 77 (Suppl 4): S33-S45. https://doi.org/10.1227/NEU.0000000000000947.
Kim DH, Vaccaro AR. Osteoporotic compression fractures of the spine; current options and considerations for treatment. Spine J 2006; 6: 479-487. https://doi.org/10.1016/j.spinee.2006.04.013.
Papaioannou A, Watts NB, Kendler DL, Yuen CK, Adachi JD, Ferko N. Diagnosis and management of vertebral fractures in elderly adults. Am J Med 2002; 113: 220-228. https://doi.org/10.1016/s0002-9343(02)01190-7.
Adachi JD, Loannidis G, Berger C et al. The influence of osteoporotic fractures on health-related quality of life in community-dwelling men and women across Canada. Osteoporos Int 2001; 12: 903-908. https://doi.org/10.1007/s001980170017.
Lotan R, Smorgick Y, Anekstein Y, Rudik O, Prosso I, Hershkovich O. Kyphoplasty for elderly patients with vertebral compression fractures - do we save lives? Mortality rates analysis comparison in a long-term follow-up cohort. Global Spine J 2021: 2192568220982282. https://doi.org/10.1177/2192568220982282.
Zhang J, He X, Fan Y, Du J, Hao D. Risk factors for conservative treatment failure in acute osteoporotic vertebral compression fractures (OVCFs). Arch Osteoporos 2019; 14: 24. https://doi.org/10.1007/s11657-019-0563-8.
Kim HJ, Park S, Park SH et al. Prevalence of frailty in patients with osteoporotic vertebral compression fracture and its association with numbers of fractures. Yonsei Med J 2018; 59: 317-324. doi: https://doi.org/10.3349/ymj.2018.59.2.317
Fried LP, Tangen CM, Walston J et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56: M146-M156. https://doi.org/10.1093/gerona/56.3.m146.
Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. Scientific World Journal 2001; 1: 323-336. https://doi.org/10.1100/tsw.2001.58.
Gilbert T, Neuburger J, Kraindler J et al. Development and validation of a Hospital Frailty Risk Score focusing on older people in acute care settings using electronic hospital records: an observational study. Lancet 2018; 391: 1775-1782. https://doi.org/10.1016/s0140-6736(18)30668-8.
Meyer M, Parik L, Leiss F, Renkawitz T, Grifka J, Weber M. Hospital frailty risk score predicts adverse events in primary total hip and knee arthroplasty. J Arthroplasty 2020; 35: 3498-3504 e3. https://doi.org/10.1016/j.arth.2020.06.087.
Nagai K, Tanaka T, Kodaira N, Kimura S, Takahashi Y, Nakayama T. Data resource profile: JMDC claims databases sourced from medical institutions. J Gen Fam Med 2020; 21: 211-218. https://doi.org/10.1002/jgf2.367.
Shimizu A, Maeda K, Wakabayashi H et al. Predictive validity of body mass index cutoff values used in the global leadership initiative on malnutrition criteria for discriminating severe and moderate malnutrition based on in-patients with pneumonia in Asians. JPEN J Parenter Enteral Nutr 2021; 45: 941-950. https://doi.org/10.1002/jpen.1959.
Mahoney FI, Barthel DW. Functional evaluation: the Barthel index. Md State Med J 1965; 14: 61-65.
D'Hoore W, Bouckaert A, Tilquin C. Practical considerations on the use of the Charlson comorbidity index with administrative data bases. J Clin Epidemiol 1996; 49: 1429-1433. https://doi.org/10.1016/s0895-4356(96)00271-5.
Hasan O, Barkat R, Rabbani A, Rabbani U, Mahmood F, Noordin S. Charlson comorbidity index predicts postoperative complications in surgically treated hip fracture patients in a tertiary care hospital: retrospective cohort of 1045 patients. Int J Surg 2020; 82: 116-120. https://doi.org/10.1016/j.ijsu.2020.08.017.
Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatr 2017; 17: 230. https://doi.org/10.1186/s12877-017-0621-2.
Kundi H, Wadhera RK, Strom JB et al. Association of frailty with 30-day outcomes for acute myocardial infarction, heart failure, and pneumonia among elderly adults. JAMA Cardiol 2019; 4: 1084-1091. https://doi.org/10.1001/jamacardio.2019.3511.
Nghiem S, Afoakwah C, Scuffham P, Byrnes J. Hospital frailty risk score and adverse health outcomes: evidence from longitudinal record linkage cardiac data. Age Ageing 2021; 50: 1778-1784. https://doi.org/10.1093/ageing/afab073.
Kobata T, Hasebe K, Momosaki R. Effectiveness of early rehabilitation for vertebral compression fractures: a retrospective cohort study. J Geriatr Phys Ther 2020; 44: 139-143. https://doi.org/10.1519/JPT.0000000000000267.
Hannah TC, Neifert SN, Caridi JM et al. Utility of the hospital frailty risk score for predicting adverse outcomes in degenerative spine surgery cohorts. Neurosurgery 2020; 87: 1223-1230. https://doi.org/10.1093/neuros/nyaa248.
Lavelle EA, Cheney R, Lavelle WF. Mortality prediction in a vertebral compression fracture population: the ASA physical status score versus the Charlson comorbidity index. Int J Spine Surg 2015; 9: 63. https://doi.org/10.14444/2063.
Segal DN, Wilson JM, Staley C, Michael KW. The 5-item modified frailty index is predictive of 30-day postoperative complications in patients undergoing Kyphoplasty vertebral augmentation. World Neurosurg 2018; 116: e225-e231. https://doi.org/10.1016/j.wneu.2018.04.172.
Leven DM, Lee NJ, Kothari P et al. Frailty index is a significant predictor of complications and mortality after surgery for adult spinal deformity. Spine (Phila Pa 1976) 2016; 41: E1394-E1401. https://doi.org/10.1097/BRS.0000000000001886.
Gilbert T, Cordier Q, Polazzi S et al. External validation of the hospital frailty risk score in France. Age Ageing 2022; 51. https://doi.org/10.1093/ageing/afab126.
McCarthy J, Davis A. Diagnosis and management of vertebral compression fractures. Am Fam Physician 2016; 94: 44-50.
van der Maarel-Wierink CD, Vanobbergen JN, Bronkhorst EM, Schols JM, de Baat C. Meta-analysis of dysphagia and aspiration pneumonia in frail elders. J Dent Res 2011; 90: 1398-1404. https://doi.org/10.1177/0022034511422909.
Shimizu A, Maeda K, Fujishima I et al. Hospital frailty risk score predicts adverse events in older patients with hip fractures after surgery: analysis of a nationwide inpatient database in Japan. Arch Gerontol Geriatr 2021; 98: 104552. doi: https://doi.org/10.1016/j.archger.2021.104552
Meyer M, Parik L, Greimel F, Renkawitz T, Grifka J, Weber M. Hospital frailty risk score outperforms current risk stratification models in primary total hip and knee arthroplasty. J Arthroplasty 2021; 36: 1533-1542. https://doi.org/10.1016/j.arth.2020.12.002.