Hypoplasia of medial pterygoid process in sphenoid bone relates to decreased mesenchymal cell proliferation in the Runx2-haploinsufficient cleidocranial dysplasia mouse model.
Cell proliferation
Mesenchymal cell
Runx2
Secondary cartilage
Sphenoid bone
Journal
Archives of oral biology
ISSN: 1879-1506
Titre abrégé: Arch Oral Biol
Pays: England
ID NLM: 0116711
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
17
11
2021
revised:
23
12
2021
accepted:
21
01
2022
pubmed:
2
2
2022
medline:
19
2
2022
entrez:
1
2
2022
Statut:
ppublish
Résumé
Hypoplasia of the medial pterygoid process of the sphenoid bone is a distinct skeletal phenotype in runt-related transcription factor 2 (Runx2) heterozygous mice and patients with cleidocranial dysplasia. The aim of this study was to investigate the involvement of Runx2 in hypoplasia by regulating cell proliferation in the mesenchymal cell condensation region. A total of thirty mouse embryos were used. The medial pterygoid process region in the Runx2 In embryonic day 14.5, mesenchymal cell condensation appeared at the future medial pterygoid process in Runx2 The present study demonstrates that Runx2 is involved in cell proliferation in the mesenchymal cell condensation region of the medial pterygoid process during mouse embryonic development.
Identifiants
pubmed: 35101837
pii: S0003-9969(22)00014-0
doi: 10.1016/j.archoralbio.2022.105358
pii:
doi:
Substances chimiques
Core Binding Factor Alpha 1 Subunit
0
Runx2 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105358Informations de copyright
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