Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor.
Journal
Cell discovery
ISSN: 2056-5968
Titre abrégé: Cell Discov
Pays: England
ID NLM: 101661034
Informations de publication
Date de publication:
01 Feb 2022
01 Feb 2022
Historique:
received:
16
09
2021
accepted:
05
12
2021
entrez:
1
2
2022
pubmed:
2
2
2022
medline:
2
2
2022
Statut:
epublish
Résumé
Regenerative capacity declines throughout evolution and with age. In this study, we asked whether metabolic programs underlying regenerative capability might be conserved across species, and if so, whether such metabolic drivers might be harnessed to promote tissue repair. To this end, we conducted metabolomic analyses in two vertebrate organ regeneration models: the axolotl limb blastema and antler stem cells. To further reveal why young individuals have higher regenerative capacity than the elderly, we also constructed metabolic profiles for primate juvenile and aged tissues, as well as young and aged human stem cells. In joint analyses, we uncovered that active pyrimidine metabolism and fatty acid metabolism correlated with higher regenerative capacity. Furthermore, we identified a set of regeneration-related metabolite effectors conserved across species. One such metabolite is uridine, a pyrimidine nucleoside, which can rejuvenate aged human stem cells and promote regeneration of various tissues in vivo. These observations will open new avenues for metabolic intervention in tissue repair and regeneration.
Identifiants
pubmed: 35102134
doi: 10.1038/s41421-021-00361-3
pii: 10.1038/s41421-021-00361-3
pmc: PMC8803930
doi:
Types de publication
Journal Article
Langues
eng
Pagination
6Informations de copyright
© 2022. The Author(s).
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