Synthetic Neoglycoconjugates of Hepta- and Nonamannoside Ligands for Eliciting Oligomannose-Specific HIV-1-Neutralizing Antibodies.

Antibodies, Neutralizing Epitopes / chemistry HIV Antibodies / chemistry HIV-1 Humans Ligands Male
HIV/AIDS glycoconjugates glycosylation oligomannosides synthesis

Journal

Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360

Informations de publication

Date de publication:
05 04 2022
Historique:
revised: 01 02 2022
received: 28 01 2022
pubmed: 2 2 2022
medline: 8 4 2022
entrez: 1 2 2022
Statut: ppublish

Résumé

Oligomannose-type glycans on the spike protein of HIV-1 constitute relevant epitopes to elicit broadly neutralizing antibodies (bnAbs). Herein we describe an improved synthesis of α- and β-linked hepta- and nonamannosyl ligands that were subsequently converted into BSA and CRM

Identifiants

DOI: 10.1002/cbic.202200061 PMID: 35104013 PMC: PMC9108342
pubmed: 35104013
doi: 10.1002/cbic.202200061
pmc: PMC9108342
mid: NIHMS1801167
doi:

Substances chimiques

Antibodies, Neutralizing 0
Epitopes 0
HIV Antibodies 0
Ligands 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202200061

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI134299
Pays : United States

Informations de copyright

© 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH.

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Auteurs

Matteo Cattin (M)

Department of Chemistry, University of Natural Resources and Life Sciences-Vienna, Muthgasse 18, Wien, A-1190, Vienna, Austria.
ORCID: 0000-0002-4926-3384

Jean-François Bruxelle (JF)

Faculty of Health Sciences and Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, British Columbia, V5A1S6, Canada.
Present address: CIRI-Centre International de Recherche en Infectiologie, University of Lyon, Inserm, U1111, CNRS, UMR5308, ENS Lyon, 46 Allée d'Italie, 69007, Lyon, France.

Kurtis Ng (K)

Faculty of Health Sciences and Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, British Columbia, V5A1S6, Canada.
ORCID: 0000-0001-7528-4624

Markus Blaukopf (M)

Department of Chemistry, University of Natural Resources and Life Sciences-Vienna, Muthgasse 18, Wien, A-1190, Vienna, Austria.
ORCID: 0000-0002-9649-1064

Ralph Pantophlet (R)

Faculty of Health Sciences and Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, British Columbia, V5A1S6, Canada.
ORCID: 0000-0003-0490-4747

Paul Kosma (P)

Department of Chemistry, University of Natural Resources and Life Sciences-Vienna, Muthgasse 18, Wien, A-1190, Vienna, Austria.
ORCID: 0000-0001-5342-7161

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Synthetic Neoglycoconjugates of Hepta- and...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Synthetic Neoglycoconjugates of Hepta- and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Anticorps antideltarétrovirus › Anticorps anti-VIH › Synthetic Neoglycoconjugates of Hepta- and...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Synthetic Neoglycoconjugates of Hepta- and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthetic Neoglycoconjugates of Hepta- and...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Synthetic Neoglycoconjugates of Hepta- and...