Genetic Associations and Architecture of Asthma-COPD Overlap.

Asthma / diagnosis Genome-Wide Association Study Humans Lung Pulmonary Disease, Chronic Obstructive / complications Smoking / genetics
COPD asthma epidemiology genome-wide association study spirometry

Journal

Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335

Informations de publication

Date de publication:
05 2022
Historique:
received: 02 06 2021
revised: 17 11 2021
accepted: 21 12 2021
pubmed: 2 2 2022
medline: 11 5 2022
entrez: 1 2 2022
Statut: ppublish

Résumé

Some people have characteristics of both asthma and COPD (asthma-COPD overlap), and evidence suggests they experience worse outcomes than those with either condition alone. What is the genetic architecture of asthma-COPD overlap, and do the determinants of risk for asthma-COPD overlap differ from those for COPD or asthma? We conducted a genome-wide association study in 8,068 asthma-COPD overlap case subjects and 40,360 control subjects without asthma or COPD of European ancestry in UK Biobank (stage 1). We followed up promising signals (P < 5 × 10 We selected 31 independent variants for further investigation in stage 2, and discovered eight novel signals (P < 5 × 10 We identified eight signals for asthma-COPD overlap, which may represent loci that predispose to type 2 inflammation, and serious long-term consequences of asthma.

Sections du résumé

BACKGROUND
Some people have characteristics of both asthma and COPD (asthma-COPD overlap), and evidence suggests they experience worse outcomes than those with either condition alone.
RESEARCH QUESTION
What is the genetic architecture of asthma-COPD overlap, and do the determinants of risk for asthma-COPD overlap differ from those for COPD or asthma?
STUDY DESIGN AND METHODS
We conducted a genome-wide association study in 8,068 asthma-COPD overlap case subjects and 40,360 control subjects without asthma or COPD of European ancestry in UK Biobank (stage 1). We followed up promising signals (P < 5 × 10
RESULTS
We selected 31 independent variants for further investigation in stage 2, and discovered eight novel signals (P < 5 × 10
INTERPRETATION
We identified eight signals for asthma-COPD overlap, which may represent loci that predispose to type 2 inflammation, and serious long-term consequences of asthma.

Identifiants

DOI: 10.1016/j.chest.2021.12.674 PMID: 35104449 PMC: PMC9131047
pubmed: 35104449
pii: S0012-3692(22)00198-2
doi: 10.1016/j.chest.2021.12.674
pmc: PMC9131047
pii:
doi:

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1155-1166

Subventions

Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P00167X/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : K23 HL136851
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : British Heart Foundation
ID : AA/18/3/34220
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N011317/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1000861
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL137927
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204801/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 202849/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT202849/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19004
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00006/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : K01 HL153941
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147148
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL089856
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL142992
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

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Auteurs

Catherine John (C)

Department of Health Sciences, University of Leicester, Leicester, England. Electronic address: cj153@leicester.ac.uk.

Anna L Guyatt (AL)

Department of Health Sciences, University of Leicester, Leicester, England.

Nick Shrine (N)

Department of Health Sciences, University of Leicester, Leicester, England.

Richard Packer (R)

Department of Health Sciences, University of Leicester, Leicester, England.

Thorunn A Olafsdottir (TA)

deCODE Genetics/Amgen, Reykjavik, Iceland.

Jiangyuan Liu (J)

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Lystra P Hayden (LP)

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Su H Chu (SH)

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Jukka T Koskela (JT)

Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

Jian'an Luan (J)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, England.

Xingnan Li (X)

Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ.

Natalie Terzikhan (N)

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.

Hanfei Xu (H)

Department of Biostatistics, Boston University School of Public Health, Boston, MA.

Traci M Bartz (TM)

Cardiovascular Health Research Unit, Department of Medicine and Department of Biostatistics, University of Washington, Seattle, WA.

Hans Petersen (H)

Lovelace Respiratory Research Institute, Albuquerque, NM.

Shuguang Leng (S)

Division of Epidemiology, Biostatistics, and Preventive Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, NM.

Steven A Belinsky (SA)

Lovelace Respiratory Research Institute, Albuquerque, NM.

Aivaras Cepelis (A)

Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Levanger, Norway.

Ana I Hernández Cordero (AI)

Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.

Ma'en Obeidat (M)

Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.

Gudmar Thorleifsson (G)

deCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.

Deborah A Meyers (DA)

Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ.

Eugene R Bleecker (ER)

Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ.

Lori C Sakoda (LC)

Division of Research, Kaiser Permanente of Northern California, Oakland, CA.

Carlos Iribarren (C)

Division of Research, Kaiser Permanente of Northern California, Oakland, CA.

Yohannes Tesfaigzi (Y)

Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Sina A Gharib (SA)

Computational Medicine Core, Center for Lung Biology and UW Medicine Sleep Center, Medicine, University of Washington, Seattle, WA.

Josée Dupuis (J)

Cardiovascular Health Research Unit, Department of Medicine and Department of Biostatistics, University of Washington, Seattle, WA.

Guy Brusselle (G)

Department of Biostatistics, Boston University School of Public Health, Boston, MA; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.

Lies Lahousse (L)

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands; Department of Bioanalysis, Ghent University, Ghent, Belgium.

Victor E Ortega (VE)

Department of Medicine, Wake Forest School of Medicine, Winston-Salem, NC.

Ingileif Jonsdottir (I)

deCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.

Don D Sin (DD)

Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada.

Yohan Bossé (Y)

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Quebec, QC, Canada.

Maarten van den Berge (M)

Department of Pulmonology, University Medical Center Groningen, University of Groningen, and GRIAC Research Institute, Groningen, the Netherlands.

David Nickle (D)

Global Health, University of Washington, Seattle, WA; Gossamer Bio, San Diego, CA.

Jennifer K Quint (JK)

National Heart and Lung Institute, Imperial College London, London, UK.

Ian Sayers (I)

Division of Respiratory Medicine and NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, England; Biodiscovery Institute, University of Nottingham, Nottingham, England.

Ian P Hall (IP)

Division of Respiratory Medicine and NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, England.

Claudia Langenberg (C)

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, England.

Samuli Ripatti (S)

Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Broad Institute of MIT and Harvard, Cambridge, MA.

Tarja Laitinen (T)

Division of Medicine, Department of Pulmonary Diseases, Turku University Hospital, Turku, Finland; Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland.

Ann C Wu (AC)

Center for Healthcare Research in Pediatrics (CHeRP) and PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA.

Jessica Lasky-Su (J)

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Per Bakke (P)

Department of Clinical Science, University of Bergen, Bergen, Norway.

Amund Gulsvik (A)

Department of Clinical Science, University of Bergen, Bergen, Norway.

Craig P Hersh (CP)

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Caroline Hayward (C)

MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.

Arnulf Langhammer (A)

Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Levanger, Norway.

Ben Brumpton (B)

K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Clinic of Thoracic and Occupational Medicine, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.

Kari Stefansson (K)

deCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.

Michael H Cho (MH)

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Louise V Wain (LV)

Department of Health Sciences, University of Leicester, Leicester, England; Leicester NIHR Biomedical Research Centre, Leicester, England.

Martin D Tobin (MD)

Department of Health Sciences, University of Leicester, Leicester, England; Leicester NIHR Biomedical Research Centre, Leicester, England.

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Genetic Associations and Architecture of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genetic Associations and Architecture of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic Associations and Architecture of...
questionsmedicales.fr › Appareil respiratoire › Poumon › Genetic Associations and Architecture of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Broncho-pneumopathie chronique obstructive › Genetic Associations and Architecture of...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Fumer › Genetic Associations and Architecture of...