A community challenge for a pancancer drug mechanism of action inference from perturbational profile data.
DREAM challenge
community challenge
pharmacogenomics
polypharmacology
Journal
Cell reports. Medicine
ISSN: 2666-3791
Titre abrégé: Cell Rep Med
Pays: United States
ID NLM: 101766894
Informations de publication
Date de publication:
18 01 2022
18 01 2022
Historique:
received:
05
02
2021
revised:
08
08
2021
accepted:
15
12
2021
entrez:
2
2
2022
pubmed:
3
2
2022
medline:
5
3
2022
Statut:
epublish
Résumé
The Columbia Cancer Target Discovery and Development (CTD2) Center is developing PANACEA, a resource comprising dose-responses and RNA sequencing (RNA-seq) profiles of 25 cell lines perturbed with ∼400 clinical oncology drugs, to study a tumor-specific drug mechanism of action. Here, this resource serves as the basis for a DREAM Challenge assessing the accuracy and sensitivity of computational algorithms for
Identifiants
pubmed: 35106508
doi: 10.1016/j.xcrm.2021.100492
pii: S2666-3791(21)00369-4
pmc: PMC8784774
doi:
Substances chimiques
RNA, Messenger
0
Protein Kinases
EC 2.7.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100492Subventions
Organisme : NCI NIH HHS
ID : U01 CA217862
Pays : United States
Organisme : NIH HHS
ID : S10 OD021764
Pays : United States
Organisme : NIH HHS
ID : S10 OD012351
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA168426
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA217858
Pays : United States
Informations de copyright
© 2021.
Déclaration de conflit d'intérêts
A.C. is founder, equity holder, and consultant of DarwinHealth, Inc., a company that has licensed the PANACEA database used in this manuscript from Columbia University. Columbia University is also an equity holder in DarwinHealth, Inc. J.S.-R. has received funding from GSK and Sanofi and personal fees from Travere Therapeutics. B.S. received consultation fees from Turbine, Ltd. All other authors declare no competing interests.
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