Perturbation of Alphavirus and Flavivirus Infectivity by Components of the Bacterial Cell Wall.


Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
23 03 2022
Historique:
pubmed: 3 2 2022
medline: 29 4 2022
entrez: 2 2 2022
Statut: ppublish

Résumé

The impact of the host microbiota on arbovirus infections is currently not well understood. Arboviruses are viruses transmitted through the bites of infected arthropods, predominantly mosquitoes or ticks. The first site of arbovirus inoculation is the biting site in the host skin, which is colonized by a complex microbial community that could possibly influence arbovirus infection. We demonstrated that preincubation of arboviruses with certain components of the bacterial cell wall, including lipopolysaccharides (LPS) of some Gram-negative bacteria and lipoteichoic acids or peptidoglycan of certain Gram-positive bacteria, significantly reduced arbovirus infectivity

Identifiants

pubmed: 35107376
doi: 10.1128/jvi.00060-22
pmc: PMC8941878
doi:

Substances chimiques

Lipopolysaccharides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0006022

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Auteurs

Lana Langendries (L)

Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

Sofie Jacobs (S)

Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

Rana Abdelnabi (R)

Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

Sam Verwimp (S)

Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

Suzanne Kaptein (S)

Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

Pieter Baatsen (P)

VIB-KU Leuven, Electron Microscopy Platform of VIB Bio Imaging Core, Leuven, Belgium.

Lieve Van Mellaert (L)

Department of Microbiology, Immunology and Transplantation, Laboratory of Molecular Bacteriology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

Leen Delang (L)

Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

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Classifications MeSH