Human iPSC-Derived Neural Models for Studying Alzheimer's Disease: from Neural Stem Cells to Cerebral Organoids.
Alzheimer’s disease
Astrocytes
Cerebral organoids
In vitro differentiation
Microglia
Neural differentiation
Neural progenitors
Neural stem cells
Neurons
iPSCs
Journal
Stem cell reviews and reports
ISSN: 2629-3277
Titre abrégé: Stem Cell Rev Rep
Pays: United States
ID NLM: 101752767
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
accepted:
28
08
2021
pubmed:
3
2
2022
medline:
6
4
2022
entrez:
2
2
2022
Statut:
ppublish
Résumé
During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used to study mechanisms of human neural development, disease modeling, and drug discovery in vitro. Especially in the field of Alzheimer's disease (AD), where this treatment is lacking, tremendous effort has been put into the investigation of molecular mechanisms behind this disease using induced pluripotent stem cell-based models. Numerous of these studies have found either novel regulatory mechanisms that could be exploited to develop relevant drugs for AD treatment or have already tested small molecules on in vitro cultures, directly demonstrating their effect on amelioration of AD-associated pathology. This review thus summarizes currently used differentiation strategies of induced pluripotent stem cells towards neuronal and glial cell types and cerebral organoids and their utilization in modeling AD and potential drug discovery.
Identifiants
pubmed: 35107767
doi: 10.1007/s12015-021-10254-3
pii: 10.1007/s12015-021-10254-3
pmc: PMC8930932
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
792-820Informations de copyright
© 2021. The Author(s).
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