Structural brain correlates of burnout severity in medical professionals: A voxel-based morphometric study.
Adult
Brain
/ diagnostic imaging
Burnout, Professional
/ diagnostic imaging
COVID-19
Cerebral Cortex
/ diagnostic imaging
Depersonalization
Emotions
Female
Gray Matter
/ diagnostic imaging
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Nurses
Pandemics
Prefrontal Cortex
/ diagnostic imaging
Self Report
Surveys and Questionnaires
Thalamus
/ diagnostic imaging
Young Adult
Burnout
Insula
Magnetic resonance imaging
Medial prefrontal cortex
Thalamus
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
16 02 2022
16 02 2022
Historique:
received:
15
10
2021
revised:
13
01
2022
accepted:
25
01
2022
pubmed:
3
2
2022
medline:
25
2
2022
entrez:
2
2
2022
Statut:
ppublish
Résumé
Occupational burnout has become a pervasive problem, especially among medical professionals who are highly vulnerable to burnout. Since the beginning of the COVID-19 pandemic, medical professionals have faced greater levels of stress. It is critical to increase our understanding of the neurobiological mechanisms of burnout among medical professionals for the benefit of healthcare systems. Therefore, in this study, we investigated structural brain correlates of burnout severity in medical professionals using a voxel-based morphometric technique. Nurses in active service underwent structural magnetic resonance imaging. Two core dimensions of burnout, namely, emotional exhaustion and depersonalization, were assessed using self-reported psychological questionnaires. Levels of emotional exhaustion were found to be negatively correlated with gray matter (GM) volumes in the bilateral ventromedial prefrontal cortex (vmPFC) and left insula. Moreover, levels of depersonalization were negatively correlated with GM volumes in the left vmPFC and left thalamus. Altogether, these findings contribute to a better understanding of the neural mechanisms of burnout and may provide helpful insights for developing effective interventions for medical professionals.
Identifiants
pubmed: 35108589
pii: S0304-3940(22)00041-6
doi: 10.1016/j.neulet.2022.136484
pmc: PMC9758014
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
136484Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Références
Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4385-4391
pubmed: 32041879
J Affect Disord. 2014 Aug;165:170-5
pubmed: 24882196
Neuroimage. 2000 Jun;11(6 Pt 1):805-21
pubmed: 10860804
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Neuroimage Clin. 2020;27:102337
pubmed: 32652491
Sci Rep. 2016 Sep 09;6:33171
pubmed: 27611212
Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15265-70
pubmed: 15469927
Transl Psychiatry. 2014 Jun 03;4:e393
pubmed: 24893064
J Affect Disord. 2015 Mar 15;174:397-9
pubmed: 25553399
Eur Neuropsychopharmacol. 2018 Dec;28(12):1371-1381
pubmed: 30243683
Neuroimage. 2011 Feb 1;54(3):2492-502
pubmed: 20946964
J Psychiatr Res. 2021 May;137:298-302
pubmed: 33735720
Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8837-42
pubmed: 27432990
Sci Rep. 2017 Oct 6;7(1):12731
pubmed: 28986553
Adv Med Sci. 2018 Mar;63(1):192-198
pubmed: 29175078
Cereb Cortex. 2013 Mar;23(3):739-49
pubmed: 22437053
Neuropsychopharmacology. 2015 Feb;40(3):537-45
pubmed: 25212487
Neurosci Lett. 2011 Mar 10;491(1):31-4
pubmed: 21215297
Neuropsychopharmacology. 2016 Feb;41(3):791-801
pubmed: 26171720
Neurosci Lett. 2021 Apr 1;749:135716
pubmed: 33592303
PLoS One. 2014 Sep 03;9(9):e104550
pubmed: 25184294
Hum Brain Mapp. 2018 Jul;39(7):2972-2986
pubmed: 29569801
Neuroimage. 2003 Jul;19(3):1233-9
pubmed: 12880848
Front Psychol. 2015 Feb 05;5:1550
pubmed: 25698984
Neurosci Biobehav Rev. 2016 Oct;69:299-312
pubmed: 27531235
Cereb Cortex. 2018 Mar 1;28(3):894-906
pubmed: 28108490
Neuroimage. 2011 Apr 1;55(3):1178-88
pubmed: 21211567
Neuroimage Clin. 2019;22:101697
pubmed: 30739844
Cereb Cortex. 2015 Jun;25(6):1554-64
pubmed: 24352030
Brain Res. 2011 Sep 9;1411:98-107
pubmed: 21813114
Psychiatry Res Neuroimaging. 2017 Nov 30;269:17-25
pubmed: 28917154
J Med Syst. 2020 Jan 2;44(2):45
pubmed: 31897774
Neuroimage. 2007 Oct 15;38(1):95-113
pubmed: 17761438
Cortex. 2018 Oct;107:92-101
pubmed: 29248158
Front Psychiatry. 2013 Oct 15;4:131
pubmed: 24133462
J Pain. 2013 Dec;14(12):1573-84
pubmed: 24135432
Int J Nurs Stud. 2010 Oct;47(10):1299-309
pubmed: 20359710
Sci Rep. 2021 Sep 14;11(1):18225
pubmed: 34521947
J Clin Neurophysiol. 2017 Jul;34(4):300-306
pubmed: 28644199
Psychiatry Clin Neurosci. 2015 Feb;69(2):123-4
pubmed: 25040875
JAMA Netw Open. 2020 Mar 2;3(3):e203976
pubmed: 32202646
PLoS One. 2013 Jun 11;8(6):e64065
pubmed: 23776438
Neurosci Res. 2011 Jun;70(2):206-13
pubmed: 21300113
Psychiatry Clin Neurosci. 2021 Jan;75(1):24-25
pubmed: 33225480
Neurosci Lett. 2021 Jan 10;741:135376
pubmed: 33221476
Psychiatry Clin Neurosci. 2006 Jun;60(3):332-9
pubmed: 16732750
Hum Brain Mapp. 2013 Nov;34(11):2808-16
pubmed: 22807242
Neuropsychopharmacology. 2012 Feb;37(3):734-45
pubmed: 22030709
Front Psychol. 2019 Jan 30;10:91
pubmed: 30761046
Acta Paediatr. 2016 Jun;105(6):705-13
pubmed: 26896193
Int J Mol Sci. 2021 Feb 09;22(4):
pubmed: 33572198
Psychiatry Res. 2009 Jun 30;172(3):226-34
pubmed: 19349151
Annu Rev Neurosci. 2018 Jul 8;41:163-183
pubmed: 29618284