Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells.

Animals Breast Neoplasms / genetics Cell Line, Tumor Female Humans Mice Mice, Inbred C57BL Neoplasms, Experimental Neoplastic Stem Cells Phenotype Tumor Microenvironment / physiology Tumor-Associated Macrophages / physiology

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
02 02 2022
Historique:
received: 12 03 2021
accepted: 07 01 2022
entrez: 3 2 2022
pubmed: 4 2 2022
medline: 16 2 2022
Statut: epublish

Résumé

Metastases are initiated by disseminated tumor cells (DTCs) that colonize distant organs. Growing evidence suggests that the microenvironment of the primary tumor primes DTCs for dormant or proliferative fates. However, the manner in which this occurs remains poorly understood. Here, using the Window for High-Resolution Intravital Imaging of the Lung (WHRIL), we study the live lung longitudinally and follow the fate of individual DTCs that spontaneously disseminate from orthotopic breast tumors. We find that spontaneously DTCs have increased levels of retention, increased speed of extravasation, and greater survival after extravasation, compared to experimentally metastasized tumor cells. Detailed analysis reveals that a subset of macrophages within the primary tumor induces a pro-dissemination and pro-dormancy DTC phenotype. Our work provides insight into how specific primary tumor microenvironments prime a subpopulation of cells for expression of proteins associated with dissemination and dormancy.

Identifiants

DOI: 10.1038/s41467-022-28076-3 PMID: 35110548 PMC: PMC8811052
pubmed: 35110548
doi: 10.1038/s41467-022-28076-3
pii: 10.1038/s41467-022-28076-3
pmc: PMC8811052
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

626

Subventions

Organisme : NCI NIH HHS
ID : R01 CA218024
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA237851
Pays : United States
Organisme : NIGMS NIH HHS
ID : K12 GM102779
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA109182
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA200561
Pays : United States
Organisme : NIH HHS
ID : S10 OD019961
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA191430
Pays : United States
Organisme : NIH HHS
ID : S10 OD026852
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA078207
Pays : United States
Organisme : NCI NIH HHS
ID : F32 CA243350
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013330
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA196521
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Lucia Borriello (L)

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.

Anouchka Coste (A)

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Department of Surgery, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.

Brian Traub (B)

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Department of Surgery, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.

Ved P Sharma (VP)

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Integrated Imaging Program, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.

George S Karagiannis (GS)

Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Department of Microbiology and Immunology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Cancer Dormancy and Tumor Microenvironment Institute and, Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.

Yu Lin (Y)

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.

Yarong Wang (Y)

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.

Xianjun Ye (X)

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Integrated Imaging Program, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
ORCID: 0000-0002-1136-4040

Camille L Duran (CL)

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
ORCID: 0000-0002-7614-3265

Xiaoming Chen (X)

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Integrated Imaging Program, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.

Madeline Friedman (M)

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.

Maria Soledad Sosa (MS)

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Dan Sun (D)

Cancer Dormancy and Tumor Microenvironment Institute and, Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
Department of Cell Biology, Albert Einstein College of Medicine/Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.

Erica Dalla (E)

Division of Hematology and Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Deepak K Singh (DK)

Cancer Dormancy and Tumor Microenvironment Institute and, Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
Department of Cell Biology, Albert Einstein College of Medicine/Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.

Maja H Oktay (MH)

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Integrated Imaging Program, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
Cancer Dormancy and Tumor Microenvironment Institute and, Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
Department of Pathology, Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.

Julio A Aguirre-Ghiso (JA)

Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA. julio.aguirre-ghiso@einsteinmed.edu.
Integrated Imaging Program, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA. julio.aguirre-ghiso@einsteinmed.edu.
Cancer Dormancy and Tumor Microenvironment Institute and, Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY, 10461, USA. julio.aguirre-ghiso@einsteinmed.edu.
Department of Cell Biology, Albert Einstein College of Medicine/Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY, 10461, USA. julio.aguirre-ghiso@einsteinmed.edu.

John S Condeelis (JS)

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA. john.condeelis@einsteinmed.edu.
Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA. john.condeelis@einsteinmed.edu.
Department of Surgery, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA. john.condeelis@einsteinmed.edu.
Integrated Imaging Program, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA. john.condeelis@einsteinmed.edu.
Cancer Dormancy and Tumor Microenvironment Institute and, Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY, 10461, USA. john.condeelis@einsteinmed.edu.
ORCID: 0000-0001-8826-2336

David Entenberg (D)

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA. david.entenberg@einsteinmed.edu.
Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA. david.entenberg@einsteinmed.edu.
Integrated Imaging Program, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA. david.entenberg@einsteinmed.edu.
Cancer Dormancy and Tumor Microenvironment Institute and, Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY, 10461, USA. david.entenberg@einsteinmed.edu.
Department of Pathology, Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA. david.entenberg@einsteinmed.edu.
ORCID: 0000-0003-0422-7264

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Primary tumor associated macrophages activate...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Primary tumor associated macrophages activate...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Primary tumor associated macrophages activate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Primary tumor associated macrophages activate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Primary tumor associated macrophages activate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Primary tumor associated macrophages activate...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Tumeurs expérimentales › Primary tumor associated macrophages activate...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches tumorales › Primary tumor associated macrophages activate...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Primary tumor associated macrophages activate...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Primary tumor associated macrophages activate...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Macrophages associés aux tumeurs › Primary tumor associated macrophages activate...