Inhibition of the Aquaporin-1 Cation Conductance by Selected Furan Compounds Reduces Red Blood Cell Sickling.
AQP1
Piezo1 channel
RBC
cyclic GMP
erythrocyte
psickle
sickle cell anemia
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
10
2021
accepted:
06
12
2021
entrez:
3
2
2022
pubmed:
4
2
2022
medline:
4
2
2022
Statut:
epublish
Résumé
In sickle cell disease (SCD), the pathological shift of red blood cells (RBCs) into distorted morphologies under hypoxic conditions follows activation of a cationic leak current (Psickle) and cell dehydration. Prior work showed sickling was reduced by 5-hydroxylmethyl-2-furfural (5-HMF), which stabilized mutant hemoglobin and also blocked the Psickle current in RBCs, though the molecular basis of this 5-HMF-sensitive cation current remained a mystery. Work here is the first to test the hypothesis that Aquaporin-1 (AQP1) cation channels contribute to the monovalent component of Psickle. Human AQP1 channels expressed in
Identifiants
pubmed: 35111062
doi: 10.3389/fphar.2021.794791
pii: 794791
pmc: PMC8801817
doi:
Types de publication
Journal Article
Langues
eng
Pagination
794791Informations de copyright
Copyright © 2022 Chow, Cox, Pei, Anabaraonye, Nourmohammadi, Henderson, Martinac, Abdulmalik and Yool.
Déclaration de conflit d'intérêts
OA is a co-inventor on a patent application for prodrugs and derivatives of 5HMF. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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