Prevalence of Mental Health Conditions Among 6078 Individuals With Down Syndrome in the United States.
ADHD
Down syndrome
anxiety
dementia
depression
mental health
prevalence
substance use
Journal
Journal of patient-centered research and reviews
ISSN: 2330-0698
Titre abrégé: J Patient Cent Res Rev
Pays: United States
ID NLM: 101646624
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
3
2
2022
pubmed:
4
2
2022
medline:
4
2
2022
Statut:
epublish
Résumé
Findings from a recent study of the largest documented cohort of individuals with Down syndrome (DS) in the United States described prevalence of common disease conditions and strongly suggested significant disparity in mental health conditions among these individuals as compared with age- and sex-matched individuals without DS. The retrospective, descriptive study reported herein is a follow-up to document prevalence of 58 mental health conditions across 28 years of data from 6078 individuals with DS and 30,326 age- and sex-matched controls. Patient data were abstracted from electronic medical records within a large integrated health system. In general, individuals with DS had higher prevalence of mood disorders (including depression); anxiety disorders (including obsessive-compulsive disorder); schizophrenia; psychosis (including hallucinations); pseudobulbar affect; personality disorder; dementia (including Alzheimer's disease); mental disorder due to physiologic causes; conduct disorder; tic disorder; and impulse control disorder. Conversely, the DS cohort experienced lower prevalence of bipolar I disorder; generalized anxiety, panic, phobic, and posttraumatic stress disorders; substance use disorders (including alcohol, opioid, cannabis, cocaine, and nicotine disorders); and attention-deficit/hyperactivity disorder. Prevalence of many mental health conditions in the setting of DS vastly differs from comparable individuals without DS. These findings delineate a heretofore unclear jumping-off point for ongoing research.
Identifiants
pubmed: 35111883
doi: 10.17294/2330-0698.1875
pii: jpcrr-9.1.58
pmc: PMC8772605
doi:
Types de publication
Journal Article
Langues
eng
Pagination
58-63Informations de copyright
© 2022 Aurora Health Care, Inc.
Déclaration de conflit d'intérêts
Conflicts of Interest None.
Références
J Child Neurol. 2011 Oct;26(10):1290-5
pubmed: 21628698
J Am Geriatr Soc. 2008 Dec;56(12):2311-6
pubmed: 19093931
Psychiatr Genet. 2013 Jun;23(3):95-107
pubmed: 23492931
Am Fam Physician. 2001 Sep 15;64(6):1031-8
pubmed: 11578024
Clin Genet. 2002 Nov;62(5):390-3
pubmed: 12431254
Dev Med Child Neurol. 2004 Apr;46(4):282-6
pubmed: 15077706
J Formos Med Assoc. 2008 Sep;107(9):693-703
pubmed: 18796359
Ment Retard Dev Disabil Res Rev. 2007;13(3):272-8
pubmed: 17910080
Birth Defects Res. 2019 Nov 1;111(18):1420-1435
pubmed: 31580536
Genet Med. 2013 Jan;15(1):64-9
pubmed: 22878506
Dev Med Child Neurol. 2016 Mar;58(3):246-54
pubmed: 26282180
Am J Med Genet C Semin Med Genet. 2015 Jun;169(2):135-49
pubmed: 25989505
Br J Psychiatry. 1994 Sep;165(3):399-403
pubmed: 7994516
J Patient Cent Res Rev. 2021 Apr 19;8(2):86-97
pubmed: 33898640