Prevalence of Endocrine Disorders Among 6078 Individuals With Down Syndrome in the United States.
Down syndrome
adrenal insufficiency
diabetes mellitus
endocrine diseases
prevalence
thyroid disorder
Journal
Journal of patient-centered research and reviews
ISSN: 2330-0698
Titre abrégé: J Patient Cent Res Rev
Pays: United States
ID NLM: 101646624
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
3
2
2022
pubmed:
4
2
2022
medline:
4
2
2022
Statut:
epublish
Résumé
Findings from a recent study describing prevalence of common disease conditions in the largest documented cohort of individuals with Down syndrome (DS) in the United States strongly suggested significant disparity in endocrine disorders among these individuals when compared with age- and sex-matched individuals without DS. This retrospective, descriptive study is a follow-up report documenting prevalence of 21 endocrine disorder conditions, across 28 years of data, from 6078 individuals with DS and 30,326 age- and sex-matched controls, abstracted from electronic medical records within a large integrated health system. Overall, individuals with DS experienced higher prevalence of adrenal insufficiency and Addison's disease; thyroid disorders, including hypothyroidism, hyperthyroidism, Hashimoto's disease, and Graves' disease; prolactinoma/hyperprolactinemia; diabetes insipidus; type I diabetes mellitus; and gout. Conversely, those with DS had lower prevalence of polycystic ovary syndrome and type II diabetes mellitus. Many prevalences of endocrine conditions seen in individuals with DS significantly differ relative to their non-DS matched counterparts. These varied findings warrant further exploration into how screening for and treatment of endocrine conditions may need to be approached differently for individuals with DS.
Identifiants
pubmed: 35111885
doi: 10.17294/2330-0698.1877
pii: jpcrr-9.1.70
pmc: PMC8772613
doi:
Types de publication
Journal Article
Langues
eng
Pagination
70-74Informations de copyright
© 2022 Aurora Health Care, Inc.
Déclaration de conflit d'intérêts
Conflicts of Interest None.
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