Interventions for Frailty Among Older Adults With Cardiovascular Disease: JACC State-of-the-Art Review.
aging
cardiovascular disease
frailty
interventions
older adult
Journal
Journal of the American College of Cardiology
ISSN: 1558-3597
Titre abrégé: J Am Coll Cardiol
Pays: United States
ID NLM: 8301365
Informations de publication
Date de publication:
08 02 2022
08 02 2022
Historique:
received:
24
09
2021
accepted:
03
11
2021
entrez:
4
2
2022
pubmed:
5
2
2022
medline:
26
2
2022
Statut:
ppublish
Résumé
With the aging of the world's population, a large proportion of patients seen in cardiovascular practice are older adults, but many patients also exhibit signs of physical frailty. Cardiovascular disease and frailty are interdependent and have the same physiological underpinning that predisposes to the progression of both disease processes. Frailty can be defined as a phenomenon of increased vulnerability to stressors due to decreased physiological reserves in older patients and thus leads to poor clinical outcomes after cardiovascular insults. There are various pathophysiologic mechanisms for the development of frailty: cognitive decline, physical inactivity, poor nutrition, and lack of social supports; these risk factors provide opportunity for various types of interventions that aim to prevent, improve, or reverse the development of frailty syndrome in the context of cardiovascular disease. There is no compelling study demonstrating a successful intervention to improve a global measure of frailty. Emerging data from patients admitted with heart failure indicate that interventions associated with positive outcomes on frailty and physical function are multidimensional and include tailored cardiac rehabilitation. Contemporary cardiovascular practice should actively identify patients with physical frailty who could benefit from frailty interventions and aim to deliver these therapies in a patient-centered model to optimize quality of life, particularly after cardiovascular interventions.
Identifiants
pubmed: 35115105
pii: S0735-1097(21)08257-7
doi: 10.1016/j.jacc.2021.11.029
pmc: PMC8852369
mid: NIHMS1767864
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
482-503Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL153771
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG021334
Pays : United States
Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Funding Support and Author Disclosures Drs Damluji, Xue, Bandeen-Roche, Walston, and Gerstenblith have received research funding from the Pepper Scholars Program of the Johns Hopkins University Claude D. Pepper Older Americans Independence Center, funded by the National Institute on Aging (P30-AG021334). Dr Damluji receives a mentored patient-oriented research career development award from the National Heart, Lung, and Blood Institute (K23-HL153771-01). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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