Challenges and future directions for studying effects of host genetics on the gut microbiome.
ABO Blood-Group System
/ genetics
Biological Variation, Population
Fucosyltransferases
/ genetics
Gastrointestinal Microbiome
/ genetics
Genetic Variation
Genome-Wide Association Study
Genomics
Host Microbial Interactions
Humans
Lactase
/ genetics
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Galactoside 2-alpha-L-fucosyltransferase
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
21
06
2021
accepted:
02
11
2021
pubmed:
5
2
2022
medline:
26
2
2022
entrez:
4
2
2022
Statut:
ppublish
Résumé
The human gut microbiome is a complex ecosystem that is involved in its host's metabolism, immunity and health. Although interindividual variations in gut microbial composition are mainly driven by environmental factors, some gut microorganisms are heritable and thus can be influenced by host genetics. In the past 5 years, 12 microbial genome-wide association studies (mbGWAS) with >1,000 participants have been published, yet only a few genetic loci have been consistently confirmed across multiple studies. Here we discuss the state of the art for mbGWAS, focusing on current challenges such as the heterogeneity of microbiome measurements and power issues, and we elaborate on potential future directions for genetic analysis of the microbiome.
Identifiants
pubmed: 35115688
doi: 10.1038/s41588-021-00983-z
pii: 10.1038/s41588-021-00983-z
doi:
Substances chimiques
ABO Blood-Group System
0
Fucosyltransferases
EC 2.4.1.-
Lactase
EC 3.2.1.108
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100-106Informations de copyright
© 2022. Springer Nature America, Inc.
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