Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project.

ABO Blood-Group System / genetics Bacterial Physiological Phenomena Bifidobacterium / physiology Diet Fucosyltransferases / genetics Gastrointestinal Microbiome Gastrointestinal Tract / microbiology Genetic Variation Genome, Human Genome-Wide Association Study Host Microbial Interactions Humans Lactase / genetics Metabolic Networks and Pathways Metagenome Multifactorial Inheritance Netherlands Polymorphism, Single Nucleotide Quantitative Trait Loci Sodium Chloride, Dietary Triglycerides / blood Galactoside 2-alpha-L-fucosyltransferase

Journal

Nature genetics

ISSN: 1546-1718

Titre abrégé: Nat Genet

Pays: United States

ID NLM: 9216904

Informations de publication

Date de publication:
02 2022

Historique:

received: 01 12 2020

accepted: 19 11 2021

pubmed: 5 2 2022

medline: 26 2 2022

entrez: 4 2 2022

Statut: ppublish

Résumé

Host genetics are known to influence the gut microbiome, yet their role remains poorly understood. To robustly characterize these effects, we performed a genome-wide association study of 207 taxa and 205 pathways representing microbial composition and function in 7,738 participants of the Dutch Microbiome Project. Two robust, study-wide significant (P < 1.89 × 10

Identifiants

DOI: 10.1038/s41588-021-00992-y PMID: 35115690

pubmed: 35115690

doi: 10.1038/s41588-021-00992-y

pii: 10.1038/s41588-021-00992-y

doi:

Substances chimiques

ABO Blood-Group System 0

Sodium Chloride, Dietary 0

Triglycerides 0

Fucosyltransferases EC 2.4.1.-

Lactase EC 3.2.1.108

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

143-151

Investigateurs

Raul Aguirre-Gamboa (R)

Patrick Deelen (P)

Lude Franke (L)

Jan A Kuivenhoven (JA)

Esteban A Lopera-Maya (EA)

Ilja M Nolte (IM)

Serena Sanna (S)

Harold Snieder (H)

Morris A Swertz (MA)

Judith M Vonk (JM)

Cisca Wijmenga (C)

Commentaires et corrections

Type : ErratumIn

Informations de copyright

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